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Loss of Sun2 ablates nuclear mechanosensing-driven extracellular matrix production and mitigates lung fibrosis

Emma Carley, Sandra Sandria, Xueyan Peng, et al.

Loss of MGST1 during fibroblast differentiation enhances vulnerability to oxidative stress in human heart failure

Mohamad Youness, Onne A.H.O. Ronda, Ankit Pradhan, et al.

Discussion

RIPK3 coordinates RHIM domain-dependent inflammatory transcription in neurons

Sigal B. Kofman, Lan H. Chu, Joshua M. Ames, et al.

The force loading rate drives cell mechanosensing through both reinforcement and fluidization

Ion Andreu, Bryan Falcones, Sebastian Hurst, et al.

Bromodomain Inhibition Blocks Inflammation-Induced Cardiac Dysfunction and SARS-CoV2 Infection in Pre-Clinical Models

Richard J Mills, Sean J Humphrey, Patrick RJ Fortuna, et al.

Human skeletal muscle CD90⁺ fibro-adipogenic progenitors are associated with muscle degeneration in type 2 diabetic patients

Jean Farup, Jesper Just, Frank de Paoli, et al.

A Transcriptional Switch Governing Fibroblast Plasticity Underlies Reversibility of Chronic Heart Disease

Michael Alexanian, Pawel F. Przytycki, Rudi Micheletti, et al.

Discussion

Human cardiac fibrosis-on-a-chip model recapitulates disease hallmarks and can serve as a platform for drug screening

Olya Mastikhina, Byeong-Ui Moon, Kenneth Williams, et al.

Discussion

Dynamic Erasure of Random X-Chromosome Inactivation during iPSC Reprogramming

Adrian Janiszewski, Irene Talon, Juan Song, et al.

Mitochondrial biogenesis is transcriptionally repressed in lysosomal lipid storage diseases

King Faisal Yambire, Lorena Fernandez-Mosquera, Robert Steinfeld, et al.

Old fibroblasts secrete inflammatory cytokines that drive variability in reprogramming efficiency and may affect wound healing between old individuals

Salah Mahmoudi, Elena Mancini, Alessandra Moore, et al.

Discussion

Molecular organization of integrin-based adhesion complexes in mouse Embryonic Stem Cells

Shumin Xia, Evelyn K.F. Yim, Pakorn Kanchanawong

AND

Superresolution architecture of pluripotency guarding adhesions

Aki Stubb, Camilo Guzmán, Elisa Närvä, et al.

Discussion