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Profilin 1 maintains cell cycle fidelity to prevent unscheduled genome doubling and polyploidy in cancer

Federica Scotto di Carlo, Sharon Russo, Simon Gemble, et al.

Discussion

BAF complexes maintain accessibility at stimulus-responsive chromatin and are required for transcriptional stimulus responses

Alexander O. D. Gulka, Kihoon A. Kang, Ziben Zhou, et al.

Disordered protein COSA-2 maintains crossover-specific repair compartments to ensure meiotic crossover maturation

Celja J. Uebel, Dahlia Y. Deng, Yumi Kim, et al.

Discussion

Dual inhibition of GTP-bound (ON) and GDP-bound (OFF) KRAS^G12C suppresses PI3Kα and leads to potent tumor inhibition

Katherine Parker, Samar Ghorbanpoor, Wafa Malik, et al.

Discussion

Generalization and extinction of learned fear alter primary sensory input to the brain

Michelle C. Rosenthal, Alper K. Bakir, John P. McGann

Discussion

Fear conditioning biases olfactory sensory neuron frequencies across generations

Clara W. Liff, Yasmine R. Ayman, Eliza C.B. Jaeger, et al.

Discussion

Loss of Sun2 ablates nuclear mechanosensing-driven extracellular matrix production and mitigates lung fibrosis

Emma Carley, Sandra Sandria, Xueyan Peng, et al.

Prenatal Stress Differentially Shapes Adult Behavior in Male and Female Offspring

Erbo Dong, Alison Chu, Tamar Gur, et al.

Discussion

Experimental evolution of cellular miniaturization reveals a putative mechanism for cell size evolution

Garoña Ana, Lemos Victoria Morgane, Giometto Andrea, et al.

Oxidative stress triggers RNAPII arrest through PARylation and DNA damage

Quentin A. Thomas, Liyang Wu, Emma Lesage, et al.

Discussion

Small Molecule Agonists of TREM2 Reprogram Microglia and Protect Synapses in Human Alzheimer’s Models

Hossam Nada, Shaoren Yuan, Farida El Gaamouch, et al.

A thirty-year trend of increasing clinical orientation at the National Institutes of Health

Brad L. Busse, James M. Tucker, Summer E. Allen, et al.

AND

Prediction of transformative breakthroughs in biomedical research

Matthew T. Davis, Brad L. Busse, Salsabil Arabi, et al.