Search results

Discovery of a Potent and Selective Inhibitor of Human NLRP3 with a Novel Binding Modality and Mechanism of Action

Kevin Wilhelmsen, Aditi Deshpande, Sarah Tronnes, et al.

Selected by 13 February 2025

Roberto Amadio

Discussion

Fis1 is required for the development of the dendritic mitochondrial network in pyramidal cortical neurons

Klaudia Strucinska, Parker Kneis, Travis Pennington, et al.

Selected by 11 February 2025

Felipe Del Valle Batalla

Discussion

Levetiracetam prevents Aβ42 production through SV2a-dependent modulation of App processing in alzheimer’s disease models

Nalini R. Rao, Olivia DeGulis, Toshihiro Nomura, et al.

Selected by 11 January 2025

Jawdat Sandakly

Hippocampal neuroinflammation causes sex-specific disruptions in action selection, food approach memories, and neuronal activation

Kiruthika Ganesan, Sahar Ghorbanpour, William Kendall, et al.

Selected by 22 November 2024

Nicole Bertola

alzheimer’s Disease Patient Brain Extracts Induce Multiple Pathologies in Vascularized Neuroimmune Organoids for Disease Modeling and Drug Discovery

Yanru Ji, Xiaoling Chen, Meek Connor Joseph, et al.

Selected by 07 November 2024

Manuel Lessi

The RNA binding protein HNRNPA2B1 regulates RNA abundance and motor protein activity in neurites

Joelle Lo, Katherine F. Vaeth, Gurprit Bhardwaj, et al.

Selected by 24 September 2024

Felipe Del Valle Batalla

Triglyceride metabolism controls inflammation and APOE4-associated disease states in microglia

Roxan A. Stephenson, Kory R. Johnson, Linling Cheng, et al.

Selected by 22 August 2024

Gustavo Stelzer, Marcus Oliveira

Impaired 26S proteasome causes learning and memory deficiency and induces neuroinflammation mediated by NF-κB in mice

Christa C. Huber, Eduardo Callegari, Maria Paez, et al.

Selected by 22 August 2024

Gustavo Stelzer, Marcus Oliveira

Discussion

LINC complex alterations are a hallmark of sporadic and familial ALS/FTD

Riccardo Sirtori, Michelle Gregoire, Emily Potts, et al.

Selected by 03 June 2024

Megane Rayer et al.

14-3-3 binding regulates Tau assembly and microtubule association

Janine Hochmair, Maxime C. M. van den Oetelaar, Lisa Diez, et al.

Selected by 03 May 2024

Barbora Knotkova et al.

Discussion

Mechano-dependent sorbitol accumulation supports biomolecular condensate

Stephanie Torrino, William M Oldham, Andrés R Tejedor, et al.

Selected by 07 September 2023

Teodora Piskova

A Phosphoproteomics Data Resource for Systems-level Modeling of Kinase Signaling Networks

Song Feng, James A. Sanford, Thomas Weber, et al.

Selected by 30 August 2023

Benjamin Dominik Maier