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The properties of α-synuclein secondary nuclei are dominated by the solution conditions rather than the seed fibril strain

Alessia Peduzzo, Sara Linse, Alexander K. Buell

Selected by Tessa Sinnige

Elucidating the molecular determinants of Aβ aggregation with deep mutational scanning

Vanessa E Gray, Katherine Sitko, Floriane Z. Ngako Kameni, et al.

Selected by Suzanne McDermott

NEUROD2 represses Reelin expression and controls dendrite orientation during cortical radial migration

Gizem Guzelsoy, Cansu Akkaya, Dila Atak, et al.

Selected by Theresa Pohlkamp

Spontaneous isomerization of long-lived proteins provides a molecular mechanism for the lysosomal failure observed in Alzheimer’s disease

Tyler R. Lambeth, Dylan L. Riggs, Lance E. Talbert, et al.

Selected by Joanna Cross

Dynamic Aha1 Co-Chaperone Binding to Human Hsp90

Javier Oroz, Laura J Blair, Markus Zweckstetter

Selected by Reid Alderson

Phase transition and amyloid formation by a viral protein as an additional molecular mechanism of virus-induced cell toxicity

Edoardo Salladini, Claire Debarnot, Vincent Delauzun, et al.

Selected by Tessa Sinnige

A non-canonical arm of UPR^ER mediates longevity through ER remodeling and lipophagy.

Joseph R Daniele, Ryo Higuchi-Sanabria, Vidhya Ramachandran, et al.

Selected by Sandra Franco Iborra

Integrated NMR and cryo-EM atomic-resolution structure determination of a half-megadalton enzyme complex

Diego Gauto, Leandro Estrozi, Charles Schwieters, et al.

Selected by Reid Alderson

Structure of a cytochrome-based bacterial nanowire

David J Filman, Stephen F Marino, Joy E Ward, et al.

Selected by Amberley Stephens

Cryo-EM structure of cardiac amyloid fibrils from an immunoglobulin light chain (AL) amyloidosis patient

Paolo Swuec, Francesca Lavatelli, Masayoshi Tasaki, et al.

Selected by Tessa Sinnige

OptoGranules reveal the evolution of stress granules to ALS-FTD pathology

Peipei Zhang, Baochang Fan, Peiguo Yang, et al.

Selected by Srivats Venkataramanan