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A high-coverage genome from a 200,000-year-old Denisovan

Stéphane Peyrégne, Diyendo Massilani, Yaniv Swiel, et al.

AND

A global map for introgressed structural variation and selection in humans

PingHsun Hsieh, Natthapon Soisangwan, David S. Gordon, et al.

Discussion

Decoding the Molecular Language of Proteins with Evolla

Xibin Zhou, Chenchen Han, Yingqi Zhang, et al.

Tidyplots empowers life scientists with easy code-based data visualization

Jan Broder Engler

Deep learning-based predictions of gene perturbation effects do not yet outperform simple linear methods

Constantin Ahlmann-Eltze, Wolfgang Huber, Simon Anders

Light-microscopy based dense connectomic reconstruction of mammalian brain tissue

Mojtaba R. Tavakoli, Julia Lyudchik, Michał Januszewski, et al.

Temporal constraints on enhancer usage shape the regulation of limb gene transcription

Raquel Rouco, Antonella Rauseo, Guillaume Sapin, et al.

Transcriptional profiling of human brain cortex identifies novel lncRNA-mediated networks dysregulated in amyotrophic lateral sclerosis

Alessandro Palma, Monica Ballarino

Discussion

A revised single-cell transcriptomic atlas of Xenopus embryo reveals new differentiation dynamics

Kseniya Petrova, Maksym Tretiakov, Aleksandr Kotov, et al.

Similarity metric learning on perturbational datasets improves functional identification of perturbations

Ian Smith, Petr Smirnov, Benjamin Haibe-Kains

Phospho-seq: Integrated, multi-modal profiling of intracellular protein dynamics in single cells

John D. Blair, Austin Hartman, Fides Zenk, et al.

Genetically encoded multimeric tags for intracellular protein localisation in cryo-EM

Herman KH Fung, Yuki Hayashi, Veijo T Salo, et al.

Discussion

A single cell spatial temporal atlas of skeletal muscle reveals cellular neighborhoods that orchestrate regeneration and become disrupted in aging

Yu Xin Wang, Colin A. Holbrook, James N. Hamilton, et al.

Discussion