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A High Content Screen for Mucin-1-Reducing Compounds Identifies Fostamatinib as a Candidate for Rapid Repurposing for Acute Lung Injury during the COVID-19 pandemic

Maria Alimova, Eriene-Heidi Sidhom, Abhigyan Satyam, et al.

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Anti-SARS-CoV-2 IgG from severely ill COVID-19 patients promotes macrophage hyper-inflammatory responses

Willianne Hoepel, Hung-Jen Chen, Sona Allahverdiyeva, et al.

Discussion

Severe immunodeficiency in mice lacking DNA repair factors XLF and Mri

Sergio Castañeda-Zegarra, Qindong Zhang, Amin Alirezaylavasani, et al.

Discussion

An open-source experimental framework for automation of cell biology experiments

Pavel Katunin, Ashley Cadby, Anton Nikolaev

Antibody repertoire and gene expression dynamics of diverse human B cell states during affinity maturation

Hamish W King, Nara Orban, John C Riches, et al.

Discussion

Transplantation of Muscle Stem Cell Mitochondria Rejuvenates the Bioenergetic Function of Dystrophic Muscle

Mahir Mohiuddin, Jeongmoon J. Choi, et al.

Discussion

In vivo analysis of Trypanosoma cruzi persistence foci at single cell resolution

Alexander I. Ward, Michael D. Lewis, Archie Khan, et al.

A therapeutic combination of two small molecule toxin inhibitors provides pancontinental preclinical efficacy against viper snakebite

Laura-Oana Albulescu, Chunfang Xie, Stuart Ainsworth, et al.

Discussion

Recognition of cellular RNAs by the S9.6 antibody creates pervasive artefacts when imaging RNA:DNA hybrids

John A. Smolka, Lionel A. Sanz, Stella R. Hartono, et al.

Endogenous retroviruses drive species-specific germline transcriptomes in mammals

Akihiko Sakashita, So Maezawa, Kris G. Alavattam, et al.

The LINC complex transmits integrin-dependent tension to the nuclear lamina and represses epidermal differentiation

Emma Carley*, Rachel M. Stewart*, Abigail Zieman*, et al.

The mitotic protein NuMA plays a spindle-independent role in nuclear formation and mechanics

Andrea Serra-Marques, Ronja Houtekamer, Dorine Hintzen, et al.

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NuMA interaction with chromatin is vital for proper nuclear architecture in human cells

Ashwathi Rajeevan, Riya Keshri, Sachin Kotak

A synthetic mechanogenetic gene circuit for autonomous drug delivery in engineered tissues

Robert J. Nims, Lara Pferdehirt, Noelani B. Ho, et al.