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autophagy

Preprints on autophagy and lysosomal degradation and its role in neurodegeneration and disease. Includes molecular mechanisms, upstream signalling and regulation as well as studies on pharmaceutical interventions to upregulate the process.

 

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Sandra Malmgren Hill

The autophagic membrane tether ATG2A transfers lipids between membranes

Shintaro Maeda, Chinatsu Otomo, Takanori Otomo

Selected by 12 April 2019

Sandra Malmgren Hill

Mechanical Stretch Kills Transformed Cancer Cells

Ajay Tijore, Mingxi Yao, Yu-Hsiu Wang, et al.

Selected by 03 February 2019

Joseph Jose Thottacherry

Discussion

Inactive USP14 and inactive UCHL5 cause accumulation of distinct ubiquitinated proteins in mammalian cells

Jayashree Chadchankar, Victoria Korboukh, Peter Doig, et al.

Selected by 31 January 2019

Mila Basic

Discussion

A non-canonical arm of UPR^ER mediates longevity through ER remodeling and lipophagy.

Joseph R Daniele, Ryo Higuchi-Sanabria, Vidhya Ramachandran, et al.

Selected by 07 January 2019

Sandra Franco Iborra

Reduced mitochondrial lipid oxidation leads to fat accumulation in myosteatosis

Jonathan P Gumucio, Austin H Qasawa, Patrick J Ferrara, et al.

Selected by 07 January 2019

Pablo Ranea Robles

Discussion

Atlastins mediate selective autophagy of the endoplasmic reticulum

Amos Liang, Emily Lingeman, Saba Ahmed, et al.

Selected by 16 March 2018

Nicola Stevenson

Discussion

Dynamin-2 facilitates Atg9 recycling from nascent autophagosomes

Alejandro Martorell Riera, Cinta Iriondo Martinez, Samuel Itskanov, et al.

Selected by 27 February 2018

Justin Joachim

Discussion