Search results

Remote homology and functional genetics unmask deeply preserved Scm3/HJURP orthologs in metazoans

Jeremy A. Hollis, Jason A. Stonick, Irini Topalidou, et al.

UFMylation of Pyruvate Dehydrogenase Regulates Mitochondrial Metabolism

Phong T. Nguyen, Zheng Wu, Dohun Kim, et al.

Exogenous Amyloid Sequences: Their Role in Amyloid-beta Heterotypic Aggregation

Jofre Seira Curto, Sandra Villegas, Maria Rosario Fernandez, et al.

Discussion

Liquid-Liquid Phase Separation-mediated formation of amyloid fibrils from DcpS scavenger enzymes

Aleksandra Ferenc-Mrozek, Maria Winiewska-Szajewska, Hanna Nieznańska, et al.

Discussion

4,5-dihydroxyhexanoic acid is a robust circulating and urine marker of mitochondrial disease and its severity

Owen S. Skinner, Maria Miranda, Fangcong Dong, et al.

Discussion

A potential anti-amyloidogenic therapy for type 2 diabetes based on the QbP1 peptide

María M. Tejero-Ojeda, Ada bernaus Vives, Michal Wojciechowski, et al.

Discussion

Oxidative stress triggers RNAPII arrest through PARylation and DNA damage

Quentin A. Thomas, Liyang Wu, Emma Lesage, et al.

Discussion

Human Assembloid Model of Emergent Neurotropic Enteroviruses

Christine E. Peters, Jimena Andersen, Min-Yin Li, et al.

Discussion

Detergent-Triggered Membrane Remodelling Monitored via Intramembrane Fluorescence De-Quenching

Claudia M. F. Andrews, Christopher M. Hofmair, Lauryn Roberts, et al.

Discussion

Classical enhancers couple cis-regulatory logic with transcriptional condensates and 3D genome architecture

Ville Tiusanen, Divyesh Patel, Jihan Xia, et al.

Discussion

Small Molecule Agonists of TREM2 Reprogram Microglia and Protect Synapses in Human Alzheimer’s Models

Hossam Nada, Shaoren Yuan, Farida El Gaamouch, et al.

Discussion

A thirty-year trend of increasing clinical orientation at the National Institutes of Health

brad L. busse, James M. Tucker, Summer E. Allen, et al.

AND

Prediction of transformative breakthroughs in biomedical research

Matthew T. Davis, brad L. busse, Salsabil Arabi, et al.