Keystone Symposium – Metabolic and Nutritional Control of Development and cell fate
This preList contains preprints discussed during the Metabolic and Nutritional Control of Development and Cell Fate Keystone Symposia. This conference was organized by Lydia Finley and Ralph J. DeBerardinis and held in the Wylie Center and Tupper Manor at Endicott College, Beverly, MA, United States from May 7th to 9th 2025. This meeting marked the first in-person gathering of leading researchers exploring how metabolism influences development, including processes like cell fate, tissue patterning, and organ function, through nutrient availability and metabolic regulation. By integrating modern metabolic tools with genetic and epidemiological insights across model organisms, this event highlighted key mechanisms and identified open questions to advance the emerging field of developmental metabolism.
| List by | Virginia Savy, Martin Estermann |
3D mechanical confinement directs muscle stem cell fate and function
Justin Gutkowski
Sex chromosomes shape the transcriptional landscape of the preimplantation mouse embryo
Mansi
Actin-based deformations of the nucleus control multiciliated ependymal cell differentiation
Ryan Harrison
HIF1A contributes to the survival of aneuploid and mosaic pre-implantation embryos
Anchel De Jaime Soguero
Specialized signaling centers direct cell fate and spatial organization in a limb organoid model
Ryan Harrison
Functional Diversity of Memory CD8 T cells is Spatiotemporally Imprinted
Marina Schernthanner
Notch3 is a genetic modifier of NODAL signalling for patterning asymmetry during mouse heart looping
Bhaval Parmar
OGT prevents DNA demethylation and suppresses the expression of transposable elements in heterochromatin by restraining TET activity genome-wide
Mansi
Actin polymerization drives lumen formation in a human epiblast model
Megane Rayer, Rivka Shapiro
Aurora B controls microtubule stability to regulate abscission dynamics in stem cells
Ines Jmel-Boyer
Notch is Required for Neural Progenitor Proliferation During Embryonic Eye Regrowth
Mina Basily






