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Keystone Symposium – Metabolic and Nutritional Control of Development and cell fate

This preList contains preprints discussed during the Metabolic and Nutritional Control of Development and Cell Fate Keystone Symposia. This conference was organized by Lydia Finley and Ralph J. DeBerardinis and held in the Wylie Center and Tupper Manor at Endicott College, Beverly, MA, United States from May 7th to 9th 2025. This meeting marked the first in-person gathering of leading researchers exploring how metabolism influences development, including processes like cell fate, tissue patterning, and organ function, through nutrient availability and metabolic regulation. By integrating modern metabolic tools with genetic and epidemiological insights across model organisms, this event highlighted key mechanisms and identified open questions to advance the emerging field of developmental metabolism.

 



List by Virginia Savy, Martin Estermann

3D mechanical confinement directs muscle stem cell fate and function

GaYoung Park, Josh A. Grey, Foteini Mourkioti, et al.

Selected by 30 April 2025

Justin Gutkowski

Bioengineering

Sex chromosomes shape the transcriptional landscape of the preimplantation mouse embryo

Daniel M. Snell, Wazeer Varsally, Aurélien Courtois, et al.

Selected by 11 January 2025

Mansi

Developmental Biology

Actin-based deformations of the nucleus control multiciliated ependymal cell differentiation

Marianne Basso, Alexia Mahuzier, Syed Kaabir Ali, et al.

Selected by 30 October 2024

Ryan Harrison

Developmental Biology

HIF1A contributes to the survival of aneuploid and mosaic pre-implantation embryos

Estefania Sanchez-Vasquez, Marianne E. Bronner, Magdalena Zernicka-Goetz

Selected by 11 October 2024

Anchel De Jaime Soguero

Developmental Biology

Specialized signaling centers direct cell fate and spatial organization in a limb organoid model

Evangelia Skoufa, Jixing Zhong, Oliver Kahre, et al.

Selected by 05 September 2024

Ryan Harrison

Developmental Biology

Functional Diversity of Memory CD8 T cells is Spatiotemporally Imprinted

Miguel Reina-Campos, Alexander Monell, Amir Ferry, et al.

Selected by 22 August 2024

Marina Schernthanner

Bioinformatics

Notch3 is a genetic modifier of NODAL signalling for patterning asymmetry during mouse heart looping

Tobias Holm Bønnelykke, Marie-Amandine Chabry, Emeline Perthame, et al.

Selected by 06 June 2024

Bhaval Parmar

Developmental Biology

OGT prevents DNA demethylation and suppresses the expression of transposable elements in heterochromatin by restraining TET activity genome-wide

Hugo Sepulveda, Xiang Li, Xiaojing Yue, et al.

Selected by 17 April 2024

Mansi

Developmental Biology

Actin polymerization drives lumen formation in a human epiblast model

Dhiraj Indana, Andrei Zakharov, Youngbin Lim, et al.

Selected by 05 April 2024

Megane Rayer, Rivka Shapiro

Biophysics

Aurora B controls microtubule stability to regulate abscission dynamics in stem cells

Snježana Kodba, Amber Öztop, Eri van Berkum, et al.

Selected by 19 March 2024

Ines Jmel-Boyer

Cell Biology

Notch is Required for Neural Progenitor Proliferation During Embryonic Eye Regrowth

Dylan J. Guerin, Belen Gutierrez, Baoyi Zhang, et al.

Selected by 10 March 2024

Mina Basily

Developmental Biology