Dissecting Gene Regulatory Networks Governing Human Cortical cell fate
Manuel Lessi
High-throughput single-cell CRISPRi screens stratify neurodevelopmental functions of schizophrenia-associated genes
Manuel Lessi, Riccardo Nagni
TET knockout cells transit between pluripotent states and exhibit precocious germline entry
Justin Gutkowski
Leveraging autophagy and pyrimidine metabolism to target pancreatic cancer
Hannah Pletcher
Succinate Dehydrogenase loss causes cascading metabolic effects that impair pyrimidine biosynthesis
Hannah Pletcher
A conserved differentiation program facilitates inhibitory neuron production in the developing mouse and human cerebellum
Jethro Lundie-Brown
Keystone Symposium – Metabolic and Nutritional Control of Development and cell fate
This preList contains preprints discussed during the Metabolic and Nutritional Control of Development and Cell Fate Keystone Symposia. This conference was organized by Lydia Finley and Ralph J. DeBerardinis and held in the Wylie Center and Tupper Manor at Endicott College, Beverly, MA, United States from May 7th to 9th 2025. This meeting marked the first in-person gathering of leading researchers exploring how metabolism influences development, including processes like cell fate, tissue patterning, and organ function, through nutrient availability and metabolic regulation. By integrating modern metabolic tools with genetic and epidemiological insights across model organisms, this event highlighted key mechanisms and identified open questions to advance the emerging field of developmental metabolism.
| List by | Virginia Savy, Martin Estermann |
3D mechanical confinement directs muscle stem cell fate and function
Justin Gutkowski
Sex chromosomes shape the transcriptional landscape of the preimplantation mouse embryo
Mansi
Actin-based deformations of the nucleus control multiciliated ependymal cell differentiation
Ryan Harrison
HIF1A contributes to the survival of aneuploid and mosaic pre-implantation embryos
Anchel De Jaime Soguero
Specialized signaling centers direct cell fate and spatial organization in a limb organoid model
Ryan Harrison