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Deep learning-based predictions of gene perturbation effects do not yet outperform simple linear methods

Constantin Ahlmann-Eltze, Wolfgang Huber, Simon Anders

A fine kinetic balance of interactions directs transcription factor hubs to genes

Apratim Mukherjee, Samantha Fallacaro, Puttachai Ratchasanmuang, et al.

G6b-B antibody-based cis-acting platelet receptor inhibitors (CAPRIs) as a new family of anti-thrombotic therapeutics

Alexandra Mazharian, Ophélie Bertin, Amrita Sarkar, et al.

A tension-induced morphological transition shapes the avian extra-embryonic territory

Arthur Michaut, Alexander Chamolly, Aurélien Villedieu, et al.

Discussion

Mentoring practices predictive of doctoral student outcomes in a biological sciences cohort

Reena Debray, Emily A. Dewald-Wang, Katherine K. Ennis

H₂O₂ sulfenylates CHE linking local infection to establishment of systemic acquired resistance

Lijun Cao, Heejin Yoo, Tianyuan Chen, et al.

Discussion

A transposase-derived gene required for human brain development

Luz Jubierre Zapater, Elias Rodriguez-Fos, Merce Planas-Felix, et al.

Cell polarity linked to gravity sensing is generated by protein translocation from statoliths to the plasma membrane

Takeshi Nishimura, Shogo Mori, Hiromasa Shikata, et al.

AND

Amyloplast sedimentation repolarizes LAZYs to achieve gravity sensing in plants

Jiayue Chen, Renbo Yu, Na Li, et al.

Molecular evidence of anteroposterior patterning in adult echinoderms

Laurent Formery , Paul Peluso , I. Kohnle , et al.

BRCA1/BARD1 ubiquitinates PCNA in unperturbed conditions to promote replication fork stability and continuous DNA synthesis

Daniel Salas-Lloret, Néstor García-Rodríguez, Lisanne Giebel, et al.

Lateral Line Ablation by Ototoxic Compounds Results in Distinct Rheotaxis Profiles in Larval Zebrafish

Kyle C Newton, Dovi Kacev, Simon R O Nilsson, et al.

Anxiety-like behaviors in mice unmasked: Revealing sex differences in anxiety using a novel light-heat conflict test

Sydney E. Lee, Emily K. Greenough, Paul Oancea, et al.

Discussion