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Deep learning-based predictions of gene perturbation effects do not yet outperform simple linear methods

Constantin Ahlmann-Eltze, Wolfgang Huber, Simon Anders

Selected by 11 November 2024

Benjamin Dominik Maier

Bioinformatics

Lipid-Based Transfection of Zebrafish Embryos: A Robust Protocol for Nucleic Acid Delivery

Aslihan Terzi, Tiger Liao, Adrian Jacobo

Selected by 09 May 2024

Roberto Rodríguez-Morales

Genetics

A long non-coding RNA at the cortex locus controls adaptive colouration in butterflies

Luca Livraghi, Joseph J. Hanly, Elizabeth Evans, et al.

AND

The ivory lncRNA regulates seasonal color patterns in buckeye butterflies

Richard A. Fandino, Noah K. Brady, Martik Chatterjee, et al.

AND

A micro-RNA drives a 100-million-year adaptive evolution of melanic patterns in butterflies and moths

Shen Tian, Tirtha Das Banerjee, Jocelyn Liang Qi Wee, et al.

Selected by 05 April 2024

Isabella Cisneros

Developmental Biology

crispr-dependent base editing screens identify separation of function mutants of RADX with altered RAD51 regulatory activity

Madison B. Adolph, Atharv S. Garje, Swati Balakrishnan, et al.

Selected by 06 September 2023

Jessica Chevallier, Pierre Caron

Cell Biology

crispr screens in iPSC-derived neurons reveal principles of tau proteostasis

Avi J. Samelson, Nabeela Ariqat, Justin McKetney, et al.

Selected by 21 July 2023

Kritika Mehta

Cell Biology

Glioblastoma extracellular vesicles influence glial cell hyaluronic acid deposition to promote invasiveness

Dominik Koessinger, David Novo, Anna Koessinger, et al.

Selected by 13 June 2023

Jade Chan

Cancer Biology

Interspecies blastocyst complementation generates functional rat cell-derived forebrain tissues in mice

Jia Huang, Bingbing He, Xiali Yang, et al.

Selected by 21 May 2023

Martin Estermann

Neuroscience

A deep mutational scanning platform to characterize the fitness landscape of anti-crispr proteins

Tobias Stadelmann, Daniel Heid, Michael Jendrusch, et al.

Selected by 03 September 2021

Soni Mohapatra

Bioengineering

A genome-wide knock-out screen for actors of epigenetic silencing reveals new regulators of germline genes and 2-cell like cell state

Nikhil Gupta, Lounis Yakhou, Julien Richard Albert, et al.

Selected by 15 June 2021

María Mariner-Faulí

Developmental Biology

An engineered transcriptional reporter of protein localization identifies regulators of mitochondrial and ER membrane protein trafficking in high-throughput screens

Robert Coukos, David Yao, Mateo I. Sanchez, et al.

Selected by 31 May 2021

Lorenzo Lafranchi

Bioengineering

A ciliopathy complex builds distal appendages to initiate ciliogenesis

Dhivya Kumar, Addison Rains, Vicente Herranz-Pérez, et al.

Selected by 23 March 2021

Nicola Stevenson

Biochemistry

Investigating receptor-mediated antibody transcytosis using Blood-Brain Barrier organoid arrays

Claire Simonneau, Martina Duschmalé, Alina Gavrilov, et al.

Selected by 20 February 2021

Kristina Kuhbandner

Cell Biology