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CRISPR screens in iPSC-derived neurons reveal principles of tau proteostasis

Avi J. Samelson, Nabeela Ariqat, Justin McKetney, et al.

Selected by 21 July 2023

Kritika Mehta

Cell Biology

An engineered transcriptional reporter of protein localization identifies regulators of mitochondrial and ER membrane protein trafficking in high-throughput screens

Robert Coukos, David Yao, Mateo I. Sanchez, et al.

Selected by 31 May 2021

Lorenzo Lafranchi

Bioengineering

Genome-wide crispri/a screens in human neurons link lysosomal failure to ferroptosis

Ruilin Tian, Anthony Abarientos, Jason Hong, et al.

Selected by 24 August 2020

Berrak Ugur

Genetics

Endogenous retroviruses are a source of enhancers with oncogenic potential in acute myeloid leukaemia

Özgen Deniz, Mamataz Ahmed, Christopher D. Todd, et al.

Selected by 21 April 2020

Jesus Victorino

Cancer Biology

Drug mechanism-of-action discovery through the integration of pharmacological and CRISPR screens

Emanuel Gonçalves, Aldo Segura-Cabrera, Clare Pacini, et al.

Selected by 20 March 2020

Georgina Sava

Cancer Biology

The histone chaperone FACT induces Cas9 multi-turnover behavior and modifies genome manipulation in human cells

Alan S. Wang, Leo Chen, R. Alex Wu, et al.

Selected by 20 August 2019

Nicola Stevenson

Molecular Biology

Evidence for an Integrated Gene Repression Mechanism based on mRNA Isoform Toggling in Human Cells

Ina Hollerer, Juliet C Barker, Victoria Jorgensen, et al.

Selected by 30 October 2018

Clarice Hong

Genetics