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Systematic analysis of protein targets associated with adverse events of drugs from clinical trials and post-marketing reports

Ines A. Smit, Avid M. Afzal, Chad H. G. Allen, et al.

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Toward in vivo-relevant hERG safety assessment and mitigation strategies based on relationships between non-equilibrium blocker binding, three-dimensional channel-blocker interactions, dynamic occupancy, dynamic exposure, and cellular arrhythmia

Hongbin Wan, Gianluca Selvaggio, Robert A. Pearlstein

The polyol pathway is a crucial glucose sensor in Drosophila

Hiroko Sano, Akira Nakamura, Mariko Yamane, et al.

A SARS-CoV-2-Human Protein-Protein Interaction Map Reveals Drug Targets and Potential Drug-Repurposing

David E. Gordon, Gwendolyn M. Jang, Mehdi Bouhaddou, et al.

Aberrant astrocyte protein secretion contributes to altered neuronal development in diverse disorders

Alison L.M. Caldwell, Jolene K. Diedrich, Maxim N. Shokhirev, et al.

Single-cell gene regulatory network analysis reveals new melanoma cell states and transition trajectories during phenotype switching

Jasper Wouters, Zeynep Kalender-Atak, Liesbeth Minnoye, et al.

DropSynth 2.0: high-fidelity multiplexed gene synthesis in emulsions

Angus M. Sidore, Calin Plesa, Joyce A. Samson, et al.

Gene regulatory network inference and analysis of multidrug-resistant Pseudomonas aeruginosa

Fernando Medeiros Filho, Ana Paula Barbosa do Nascimento, Marcelo Trindade dos Santos, et al.

Aequorea victoria’s secrets

Gerard G. Lambert, Hadrien Depernet, Guillaume Gotthard, et al.

Adipocyte vesicles: ‘all-in-one’ packages that stimulate tumor mitochondrial metabolism and dynamics

Emily Clement, Ikrame Lazar, Camille Attané, et al.

Charting a tissue from single-cell transcriptomes

Mor Nitzan, Nikos Karaiskos, Nir Friedman, et al.

Large-scale analyses of human microbiomes reveal thousands of small, novel genes and their predicted functions

Hila Sberro, Nicholas Greenfield, Georgios Pavlopoulos, et al.

Integrated NMR and cryo-EM atomic-resolution structure determination of a half-megadalton enzyme complex

Diego Gauto, Leandro Estrozi, Charles Schwieters, et al.