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4,5-dihydroxyhexanoic acid is a robust circulating and urine marker of mitochondrial disease and its severity

Owen S. Skinner, Maria Miranda, Fangcong Dong, et al.

Discussion

A thirty-year trend of increasing clinical orientation at the National Institutes of Health

Brad L. Busse, James M. Tucker, Summer E. Allen, et al.

AND

Prediction of transformative breakthroughs in biomedical research

Matthew T. Davis, Brad L. Busse, Salsabil Arabi, et al.

Discussion

The lipidomic architecture of the mouse brain

Luca Fusar Bassini, Halima Hannah Schede, Laura Capolupo, et al.

Discussion

Malaria shaped human spatial organisation for the last 74 thousand years

Margherita Colucci, Michela Leonardi, James Blinkhorn, et al.

Tumor-infiltrating CD27^-IgD^- regulatory B cells suppress cytotoxic CD8⁺T cell responses in renal cell carcinoma

Zara Baig, Isabella Withnell, Joseph C.F. Ng, et al.

Molecular interactome of HNRNPU reveals regulatory networks in neuronal differentiation and DNA methylation

Marika Oksanen, Francesca Mastropasqua, Krystyna Mazan-Mamczarz, et al.

Discussion

Decoding the Molecular Language of Proteins with Evolla

Xibin Zhou, Chenchen Han, Yingqi Zhang, et al.

Modular control of time and space during vertebrate axis segmentation

Ali Seleit, Ian Brettell, Tomas Fitzgerald, et al.

AND

Natural genetic variation quantitatively regulates heart rate and dimension

Jakob Gierten, Bettina Welz, Tomas Fitzgerald, et al.

Autism gene variants disrupt enteric neuron migration and cause gastrointestinal dysmotility

Kate E. McCluskey, Katherine M. Stovell, Karen Law, et al.

Experts fail to reliably detect AI-generated histological data

Jan Hartung, Stefanie Reuter, Vera Anna Kulow, et al.

Discussion

A complex Plasmodium falciparum cryptotype circulating at low frequency across the African continent

Olivo Miotto, Alfred Amambua-Ngwa, Lucas Amenga-Etego, et al.

Discussion

Pervasive sublethal effects of agrochemicals as contributing factors to insect decline

Lautaro Gandara, Richard Jacoby, François Laurent, et al.