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The loss of dna polymerase epsilon accessory subunits POLE3-POLE4 leads to BRCA1-independent PARP inhibitor sensitivity

Hasan Mamar, Roberta Fajka-Boja, Mónika Mórocz, et al.

Selected by Audrey Noireterre

Digitize your Biology! Modeling multicellular systems through interpretable cell behavior

Jeanette A.I. Johnson, Genevieve L. Stein-O’Brien, Max Booth, et al.

Selected by Benjamin Dominik Maier et al.

Tardigrades dramatically upregulate dna repair pathway genes in response to ionizing radiation

Courtney M. Clark-Hachtel, Jonathan D. Hibshman, Tristan De Buysscher, et al.

Selected by Isabella Cisneros

CRISPR-dependent base editing screens identify separation of function mutants of RADX with altered RAD51 regulatory activity

Madison B. Adolph, Atharv S. Garje, Swati Balakrishnan, et al.

Selected by Jessica Chevallier, Pierre Caron

A transposase-derived gene required for human brain development

Luz Jubierre Zapater, Elias Rodriguez-Fos, Merce Planas-Felix, et al.

Selected by Amanda Ivanoff

Polθ is phosphorylated by Polo-like kinase 1 (PLK1) to enable repair of dna double strand breaks in mitosis

Camille Gelot, Marton Tibor Kovacs, Simona Miron, et al.

Selected by Pierre Caron

EXO1-mediated dna repair by single-strand annealing is essential for BRCA1-deficient cells

B. van de Kooij, A. Schreuder, R.S. Pavani, et al.

Selected by Jennifer Ann Black

Actin nucleators safeguard replication forks by limiting nascent strand degradation

Jadwiga Nieminuszczy, Peter R. Martin, Ronan Broderick, et al.

Selected by Roberto Amadio

BRCA1/BARD1 ubiquitinates PCNA in unperturbed conditions to promote replication fork stability and continuous dna synthesis

Daniel Salas-Lloret, Néstor García-Rodríguez, Lisanne Giebel, et al.

Selected by Pierre Caron

Single-strand mismatch and damage patterns revealed by single-molecule dna sequencing

Mei Hong Liu, Benjamin Costa, Una Choi, et al.

Selected by Kerryn Elliott

Nuclear myosin VI maintains replication fork stability

Jie Shi, Kristine Hauschulte, Ivan Mikicic, et al.

Selected by Pierre Caron

Pin1-promoted SUMOylation of RNF168 restrains its chromatin accumulation

Anoop Singh Chauhan, Alexander J. Garvin, Mohammed Jamshad, et al.

Selected by Pierre Caron