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Cardioids reveal self-organizing principles of human cardiogenesis

Pablo Hofbauer, Stefan Jahnel, Nora Papai, et al.

Systematic analysis of protein targets associated with adverse events of drugs from clinical trials and post-marketing reports

Ines A. Smit, Avid M. Afzal, Chad H. G. Allen, et al.

AND

Toward in vivo-relevant hERG safety assessment and mitigation strategies based on relationships between non-equilibrium blocker binding, three-dimensional channel-blocker interactions, dynamic occupancy, dynamic exposure, and cellular arrhythmia

Hongbin Wan, Gianluca Selvaggio, Robert A. Pearlstein

Discussion

Preserved efficacy and reduced toxicity with intermittent linezolid dosing in combination with bedaquiline and pretomanid in a murine TB model

Kristina M. Bigelow, Rokeya Tasneen, Yong S. Chang, et al.

Discussion

Ribosome rescue inhibitors clear Neisseria gonorrhoeae in vivo using a new mechanism

Zachary D. Aron, Atousa Mehrani, Eric D. Hoffer, et al.

EllipTrack: A Global-Local Cell-Tracking Pipeline for 2D Fluorescence Time-Lapse Microscopy

Chengzhe Tian, Chen Yang, Sabrina L. Spencer

Discussion

In vivo analysis of Trypanosoma cruzi persistence foci at single cell resolution

Alexander I. Ward, Michael D. Lewis, Archie Khan, et al.

A therapeutic combination of two small molecule toxin inhibitors provides pancontinental preclinical efficacy against viper snakebite

Laura-Oana Albulescu, Chunfang Xie, Stuart Ainsworth, et al.

Discussion

Broad-spectrum antivirals of protoporphyrins inhibit the entry of highly pathogenic emerging viruses

Shengsheng Lu, Xiaoyan Pan, Daiwei Chen, et al.

Discussion

The antimicrobial peptide DGL13K is active against resistant gram-negative bacteria and subinhibitory concentrations stimulate bacterial growth without causing resistance

Sven-Ulrik Gorr, Hunter V. Brigman, Jadyn C. Anderson, et al.

Discussion

Biophysical forces rewire cell metabolism to guide microtubule-dependent cell mechanics

Stephanie Torrino, Stephane Audebert, Ilyes Belhadj, et al.

Kinetochore protein Spindly controls microtubule polarity in Drosophila axons

Urko del Castillo, Hans-Arno J. Müller, Vladimir I. Gelfand

Retrospective identification of rare cell populations underlying drug resistance connects molecular variability with cell fate

Benjamin L. Emert, Christopher Coté, Eduardo A. Torre, et al.