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CRISPR-dependent base editing screens identify separation of function mutants of RADX with altered RAD51 regulatory activity

Madison B. Adolph, Atharv S. Garje, Swati Balakrishnan, et al.

Selected by 06 September 2023

Jessica Chevallier, Pierre Caron

Cell Biology

Polθ is phosphorylated by Polo-like kinase 1 (PLK1) to enable repair of DNA double strand breaks in mitosis

Camille Gelot, Marton Tibor Kovacs, Simona Miron, et al.

Selected by 05 June 2023

Pierre Caron

Molecular Biology

Telomere-to-telomere human DNA replication timing profiles

Dashiell J. Massey, Amnon Koren

Selected by 04 May 2022

Jennifer Ann Black

Genomics

A live-cell marker to visualize the dynamics of stable microtubules

Klara I. Jansen, Mithila Burute, Lukas C. Kapitein

Selected by 11 July 2021

Niveda Udaykumar

Cell Biology

Biomimetic, smart and multivalent ligands for G-quadruplex isolation and bioorthogonal imaging

Francesco Rota Sperti, Thibaut Charbonnier, Pauline Lejault, et al.

Selected by 11 January 2021

Jennifer Ann Black

Biophysics

CENP-A chromatin prevents replication stress at centromeres to avoid structural aneuploidy

Simona Giunta, Solène Hervé, Ryan R. White, et al.

Selected by 10 December 2020

Sree Rama Chaitanya

Cell Biology

ARID1A regulates R-loop associated DNA replication stress

Shuhe Tsai, Emily Yun-Chia Chang, Louis-Alexandre Fournier, et al.

Selected by 05 December 2020

Sree Rama Chaitanya

Molecular Biology

SF3B1-targeted Splicing Inhibition Triggers Global Alterations in Transcriptional dynamics and R-Loop Metabolism

Daisy Castillo-Guzman, Stella R. Hartono, Lionel A. Sanz, et al.

Selected by 06 November 2020

Sree Rama Chaitanya

Molecular Biology

Live-cell imaging shows uneven segregation of extrachromosomal DNA elements and transcriptionally active extrachromosomal DNA clusters in cancer

Eunhee Yi, Amit D. Gujar, Molly Guthrie, et al.

Selected by 28 October 2020

Sree Rama Chaitanya

Cancer Biology

Functional diversification of Ser-Arg rich protein kinases to control ubiquitin-dependent neurodevelopmental signalling

Francisco Bustos, Anna Segarra-Fas, Gino Nardocci, et al.

Selected by 22 September 2020

Sree Rama Chaitanya

Developmental Biology

Single-molecule live cell imaging of the Smc5/6 DNA repair complex

Thomas J. Etheridge, Desiree Villahermosa, Anja Irmisch, et al.

Selected by 26 June 2020

Jennifer Ann Black

Molecular Biology

Pal stabilises the bacterial outer membrane during constriction by a mobilisation-and-capture mechanism

Joanna Szczepaniak, Peter Holmes, Karthik Rajasekar, et al.

Selected by 22 October 2019

Hannah Behrens