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A thirty-year trend of increasing clinical orientation at the National Institutes of Health

Brad L. Busse, James M. Tucker, Summer E. Allen, et al.

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Prediction of transformative breakthroughs in biomedical research

Matthew T. Davis, Brad L. Busse, Salsabil Arabi, et al.

Discussion

A drought stress-induced MYB transcription factor regulates pavement cell shape in leaves of European aspen (Populus tremula)

Sijia Liu, Siamsa M. Doyle, Kathryn M. Robinson, et al.

PPARδ activation in microglia drives a transcriptional response that primes phagocytic function while countering inflammatory activation

Jacob S. Deyell, Jonathan Hasselmann, Linda Stroud, et al.

Discussion

Cannibalism as a mechanism to offset reproductive costs in three-spined sticklebacks

V.I. Abuwa, A. de Flamingh, E. Arredondo, et al.

Discussion

Kosmos: An AI Scientist for Autonomous Discovery

Ludovico Mitchener, Angela Yiu, Benjamin Chang, et al.

Discussion

Tissue mechanics and systemic signaling safeguard epithelial tissue against spindle misorientation

Floris Bosveld, Baptiste Tesson, Eric van Leen, et al.

Discussion

Snake venom metalloproteinases are predominantly responsible for the cytotoxic effects of certain African viper venoms

Keirah E. Bartlett, Adam Westhorpe, Mark C. Wilkinson, et al.

Cryo-EM reveals multiple mechanisms of ribosome inhibition by doxycycline

William S. Stuart, Michail N. Isupov, Mathew McLaren, et al.

Loss of MGST1 during fibroblast differentiation enhances vulnerability to oxidative stress in human heart failure

Mohamad Youness, Onne A.H.O. Ronda, Ankit Pradhan, et al.

Discussion

Scalable transcription factor mapping uncovers the regulatory dynamics of natural and synthetic transcription factors in human T cell states

Riley D.Z. Mullins, Jesse Zaretsky, Emily Stoller, et al.

Discussion

Vitamin B12 supports skeletal muscle oxidative phosphorylation capacity in male mice

Luisa F. Castillo, Katarina E. Heyden, Abigail R. Williamson, et al.

Discussion

A high-coverage genome from a 200,000-year-old Denisovan

Stéphane Peyrégne, Diyendo Massilani, Yaniv Swiel, et al.

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A global map for introgressed structural variation and selection in humans

PingHsun Hsieh, Natthapon Soisangwan, David S. Gordon, et al.

Discussion