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Combinatorial and Inducible CRISPRa/i Enables Canalized hiPSC forward programming and Iterative Refinement via Single-Cell Genomics

Federica Sozza, Alberto Romano, Nicole D’Elia, et al.

Stem cell-derived mouse embryos develop within an extra-embryonic yolk sac to form anterior brain regions and a beating heart

Gianluca Amadei, Charlotte E Handford, Joachim De Jonghe, et al.

AND

Mouse-embryo model derived exclusively from embryonic stem cells undergo neurulation and heart development

Kasey Y.C. Lau, Hernan Rubinstein, Carlos W. Gantner, et al.

Transplantable human thyroid organoids generated from embryonic stem cells to rescue hypothyroidism

Mírian Romitti, Barbara de Faria da Fonsecaa, Gilles Doumont, et al.

FLIMJ: an open-source ImageJ toolkit for fluorescence lifetime image data analysis

Dasong Gao, Paul R Barber, Jenu V Chacko, et al.

Generative modeling of single-cell population time series for inferring cell differentiation landscapes

Grace H.T. Yeo, Sachit D. Saksena, David K. Gifford

Discussion

Interspecies differences in proteome turnover kinetics are correlated with lifespans and energetic demands

Kyle Swovick, Denis Firsanov, Kevin A. Welle, et al.

Defining totipotency using criteria of increasing stringency

Eszter Posfai, John Paul Schell, Adrian Janiszewski, et al.

Coupled active systems encode emergent behavioral dynamics of the unicellular predator Lacrymaria olor

Scott M. Coyle, Ellie M. Flaum, Hongquan Li, et al.

Discussion