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PIP5K-Ras bistability triggers plasma membrane symmetry breaking to define cellular polarity and regulate migration

Yu Deng, Tatsat Banerjee, Satomi Matsuoka, et al.

Imaging cellular activity simultaneously across all organs of a vertebrate reveals body-wide circuits

Virginia M. S. Ruetten, Wei Zheng, Igor Siwanowicz, et al.

A high-coverage genome from a 200,000-year-old Denisovan

Stéphane Peyrégne, Diyendo Massilani, Yaniv Swiel, et al.

AND

A global map for introgressed structural variation and selection in humans

PingHsun Hsieh, Natthapon Soisangwan, David S. Gordon, et al.

Discussion

Gut microbial composition modulates food-specific CD4⁺ T cells in food allergy

Alexa R Weingarden, Flannery S Dahlberg, Caroline N Broude, et al.

Aspartate transaminases are required for blood development

Narges Pourmandi, Greggory Myers, Arjun Jha, et al.

VANGL2 shapes the mouse heart tube from adjacent epithelia and without planar polarity

Paul Palmquist-Gomes, Gaëlle Letort, Ayushi U. Hegde, et al.

Molecular and functional dissection using CaMPARI-seq reveals the neuronal organization for dissociating optic flow-dependent behaviors

Koji Matsuda, Chung-Han Wang, Atsushi Toyoda, et al.

Discussion

There and back again: the dynamic evolution of panarthropod germ cell specification mechanisms

Jonchee A. Kao, Emily L. Rivard, Rishabh R. Kapoor, et al.

Discussion

Immune–tracheal intercellular signalling coordinates the muscle injury response in Drosophila

Nourhene Ammar, Olivier Josse, Aurélien Guillou, et al.

Wide-ranging behavioral dysfunction in two mouse models of pathological human variants in the GRIK2 kainate receptor gene

Brynna T. Webb, Hieu Trinh, Emily A. Breach, et al.

Discussion

TET knockout cells transit between pluripotent states and exhibit precocious germline entry

Raphaël Pantier, Elisa Barbieri, Sara Gonzalez Brito, et al.

Leveraging autophagy and pyrimidine metabolism to target pancreatic cancer

Suzanne Dufresne, Ramya S Kuna, Kristiana Wong, et al.

Discussion