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Profilin 1 maintains cell cycle fidelity to prevent unscheduled genome doubling and polyploidy in cancer

Federica Scotto di Carlo, Sharon Russo, Simon Gemble, et al.

Discussion

Comprehensive Lineage Tracing Maps the Landscape of Cell Fate Decisions in Mouse Embryogenesis

William N. Colgan, Luke W. Koblan, JoAnne Villagrana, et al.

Discussion

Defective BRCA1-mediated DNA end resection drives tandem duplication formation and FANCM synthetic lethality

Namrata M. Nilavar, Alberto Marin-Gonzalez, Francesca Menghi, et al.

Discussion

Site-Specific Inhibition of Translation Initiation via 2’-O-methylation

Adam Suh, Stephanie Mou, Emmely A. Patrasso, et al.

Discussion

Vitamin B12 supports skeletal muscle oxidative phosphorylation capacity in male mice

Luisa F. Castillo, Katarina E. Heyden, Abigail R. Williamson, et al.

Discussion

A high-coverage genome from a 200,000-year-old Denisovan

Stéphane Peyrégne, Diyendo Massilani, Yaniv Swiel, et al.

AND

A global map for introgressed structural variation and selection in humans

PingHsun Hsieh, Natthapon Soisangwan, David S. Gordon, et al.

In depth profiling of the cancer proteome from the flowthrough of standard RNA- preparation kits for precision oncology

Filip Mundt Madsen, Annelaura Bach Nielsen, Juanjuan Wang, et al.

Malaria shaped human spatial organisation for the last 74 thousand years

Margherita Colucci, Michela Leonardi, James Blinkhorn, et al.

Nucleoplasmic Lamin A/C controls replication fork restart upon stress by modulating local H3K9me3 and ADP-ribosylation levels

Veronica Cherdyntseva, Joanna Paulson, Selin Adakli, et al.

Discussion

DNA methylation enables recurrent endogenization of giant viruses in an animal relative

Luke A. Sarre, Iana V. Kim, Vladimir Ovchinnikov, et al.

2D and 3D multiplexed subcellular profiling of nuclear instability in human cancer

Shannon Coy, Brian Cheng, Jong Suk Lee, et al.

Discussion

Double-strand breaks in facultative heterochromatin require specific movements and chromatin changes for efficient repair

Marieke R. Wensveen, Aditya A. Dixit, Serafin U. Colmenares, et al.