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Behavioral characteristics of an extremely old rhesus macaque in a zoo: Dementia-like symptoms and implications for quality of life of geriatric animals

Yumi Yamanashi, Haruna Bando, Keita Niimi, et al.

Science should be machine-readable

A. Sina Booeshaghi, Laura Luebbert, Lior Pachter

Discussion

Remote homology and functional genetics unmask deeply preserved Scm3/HJURP orthologs in metazoans

Jeremy A. Hollis, Jason A. Stonick, Irini Topalidou, et al.

Classical enhancers couple cis-regulatory logic with transcriptional condensates and 3D genome architecture

Ville Tiusanen, Divyesh Patel, Jihan Xia, et al.

Discussion

Small Molecule Agonists of TREM2 Reprogram Microglia and Protect Synapses in human Alzheimer’s Models

Hossam Nada, Shaoren Yuan, Farida El Gaamouch, et al.

A thirty-year trend of increasing clinical orientation at the National Institutes of Health

Brad L. Busse, James M. Tucker, Summer E. Allen, et al.

AND

Prediction of transformative breakthroughs in biomedical research

Matthew T. Davis, Brad L. Busse, Salsabil Arabi, et al.

Citrobacter rodentium infection activates colonic lamina propria group 2 innate lymphoid cells

Rita Berkachy, Vishwas Mishra, Priyanka Biswas, et al.

Normal aging increases white matter microglial reaction and perivascular macrophages in the microcebe primate

Léo Dupuis, Lolie Garcia, Fanny Petit, et al.

Discussion

A conserved Hsp70 phosphorylation regulates cell cycle progression after DNA damage

Thomas Moss, Alexandra Wooldredge, Koustav Bhakta, et al.

FUS Mislocalization Rewires a Cortical Gene Network to Drive 2 Cognitive and Behavioral Impairment in ALS

Raphaelle CASSEL, Félicie LORENC, Aurélie BOMBARDIER, et al.

Discussion

Platelet-derived LPA16:0 inhibits adult neurogenesis and stress resilience in anxiety disorder

Thomas Larrieu, Charline Carron, Fabio Grieco, et al.

Hippocampal neuroinflammation causes sex-specific disruptions in action selection, food approach memories, and neuronal activation

Kiruthika Ganesan, Sahar Ghorbanpour, William Kendall, et al.