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A pharmacokinetic-pharmacodynamic assessment of the hepatic and bone-marrow toxicities of the new trypanoside fexinidazole

James Andrew Watson, Nathalie Strub-Wourgraft, Antoine Tarral, et al.

Selected by 18 December 2018

Zhang-He Goh

Pharmacology and Toxicology

Multi-color single molecule imaging uncovers extensive heterogeneity in mRNA decoding

Sanne Boersma, Deepak Khuperkar, Bram M.P. Verhagen, et al.

AND

Live-cell single RNA imaging reveals bursts of translational frameshifting

Kenneth R Lyon Jr, Luis U Aguilera, Tatsuya Morisaki, et al.

Selected by 18 December 2018

Nicola Stevenson

Biochemistry

Microtubules Gate Tau Condensation to Spatially Regulate Microtubule Functions

Ruensern Tan, Aileen J. Lam, Tracy Tan, et al.

AND

Kinetically distinct phases of tau on microtubules regulate kinesin motors and severing enzymes

Valerie Siahaan, Jochen Krattenmacher, Amayra Hernandez-Vega, et al.

Selected by 12 December 2018

Satish Bodakuntla

Cell Biology

Acquired interbacterial defense systems protect against interspecies antagonism in the human gut microbiome

Benjamin D. Ross, Adrian J. Verster, Matthew C. Radey, et al.

Selected by 11 December 2018

Connor Rosen

Microbiology

Psychiatric risk gene NT5C2 regulates protein translation in human neural progenitor cells

Rodrigo R.R. Duarte, Nathaniel D. Bachtel, Marie-Caroline Cotel, et al.

Selected by 07 December 2018

Joanna Cross

Neuroscience

Drosophila kinesin-8 stabilises kinetochore-microtubule interaction

Tomoya Edzuka, Gohta Goshima

Selected by 16 November 2018

Ben Craske, Gaetan Dias Mirandela, Thibault Legal and Toni McHugh

Biochemistry

Tension on kinetochore substrates is insufficient to prevent Aurora-triggered detachment

Anna K de Regt, Charles L Asbury, Sue Biggins

Selected by 11 November 2018

Angika Basant

Cell Biology

Single-cell RNA sequencing reveals novel cell differentiation dynamics during human airway epithelium regeneration

Sandra Ruiz Garcia, Marie Deprez, Kevin Lebrigand, et al.

Selected by 10 November 2018

Rob Hynds

Cell Biology

Molecular organization of integrin-based adhesion complexes in mouse Embryonic Stem Cells

Shumin Xia, Evelyn K.F. Yim, Pakorn Kanchanawong

AND

Superresolution architecture of pluripotency guarding adhesions

Aki Stubb, Camilo Guzmán, Elisa Närvä, et al.

Selected by 02 November 2018

Nicola Stevenson, Amanda Haage

Cell Biology

Evidence for an integrated Gene Repression Mechanism based on mRNA Isoform Toggling in Human Cells

ina Hollerer, Juliet C Barker, Victoria Jorgensen, et al.

Selected by 30 October 2018

Clarice Hong

Genetics

The microbial basis of impaired wound healing: differential roles for pathogens, "bystanders", and strain-level diversification in clinical outcomes

Lindsay Kalan, Jacquelyn S Meisel, Michael A Loesche, et al.

Selected by 24 October 2018

Snehal Kadam

Microbiology

PUMILIO hyperactivity drives premature aging of Norad-deficient mice

Florian Kopp, Mehmet Yalvac, Beibei Chen, et al.

Selected by 09 October 2018

Carmen Adriaens

Genetics