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OGT prevents DNA demethylation and suppresses the expression of transposable elements in heterochromatin by restraining TET activity genome-wide

Hugo Sepulveda, Xiang Li, Xiaojing Yue, et al.

RIPK3 coordinates RHIM domain-dependent inflammatory transcription in neurons

Sigal B. Kofman, Lan H. Chu, Joshua M. Ames, et al.

2D and 3D multiplexed subcellular profiling of nuclear instability in human cancer

Shannon Coy, Brian Cheng, Jong Suk Lee, et al.

Bovine blastocyst like structures derived from stem cell cultures

Carlos A. Pinzón-Arteaga, Yinjuan Wang, Yulei Wei, et al.

An Arp2/3-cPLA2-NFκB axis acts as a Cell Shape Sensor to drive Homeostatic Migration of Dendritic Cells

Zahraa Alraies, Claudia A. Rivera, Maria-Graciela Delgado, et al.

Sub-lethal apoptotic stress enables mtDNA release during senescence and drives the SASP

James Chapman, Hanna Salmonowicz, Stella Victorelli, et al.

Blockage of Lamin-A/C loss diminishes the pro-inflammatory macrophage response

Johanna L. Mehl, Ashley Earle, Jan Lammerding, et al.

Selective inhibitors of JAK1 targeting a subtype-restricted allosteric cysteine

Madeline E. Kavanagh, Benjamin D. Horning, Roli Khattri, et al.

cGAS recruitment to micronuclei is dictated by pre-existing nuclear chromatin status

Kate M. MacDonald, Shirony Nicholson-Puthenveedu, Maha M. Tageldein, et al.

Nuclear soluble cGAS senses DNA virus infection

Yakun Wu, Kun Song, Wenzhuo Hao, et al.

STING mediates immune responses in a unicellular choanoflagellate

Arielle Woznica, Ashwani Kumar, Carolyn R. Sturge, et al.

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The STING ligand 2’3’-cGAMP induces an NF-κB-dependent anti-bacterial innate immune response in the starlet sea anemone Nematostella vectensis

Shally R. Margolis, Peter A. Dietzen, Beth M. Hayes, et al.

A zebrafish model for COVID-19 recapitulates olfactory and cardiovascular pathophysiologies caused by SARS-CoV-2

Aurora Kraus, Elisa Casadei, Mar Huertas, et al.