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A genome-wide knock-out screen for actors of epigenetic silencing reveals new regulators of germline genes and 2-cell like cell state

Nikhil Gupta, Lounis Yakhou, Julien Richard Albert, et al.

Selected by 15 June 2021

María Mariner-Faulí

Developmental Biology

Enhancer-associated H3K4 methylation safeguards in vitro germline competence

Tore Bleckwehl, Giuliano Crispatzu, Kaitlin Schaaf, et al.

Selected by 13 May 2021

Sree Rama Chaitanya

Developmental Biology

Redundant mechanisms driven independently by RUNX1 and GATA2 for haematopoietic development

Erica Bresciani, Blake Carrington, Kai Yu, et al.

Selected by 16 April 2021

Tim Petzold

Developmental Biology

Mitotic R-loops direct Aurora B kinase to maintain centromeric cohesion

Erin C. Moran, Limin Liu, Ewelina Zasadzinska, et al.

Selected by 10 February 2021

Jennifer Ann Black

Cell Biology

SF3B1-targeted Splicing Inhibition Triggers Global Alterations in Transcriptional Dynamics and R-Loop Metabolism

Daisy Castillo-Guzman, Stella R. Hartono, Lionel A. Sanz, et al.

Selected by 06 November 2020

Sree Rama Chaitanya

Molecular Biology

A High Content Screen for Mucin-1-Reducing Compounds Identifies Fostamatinib as a Candidate for Rapid Repurposing for Acute Lung Injury during the COVID-19 pandemic

Maria Alimova, Eriene-Heidi Sidhom, Abhigyan Satyam, et al.

AND

Anti-SARS-CoV-2 IgG from severely ill COVID-19 patients promotes macrophage hyper-inflammatory responses

Willianne Hoepel, Hung-Jen Chen, Sona Allahverdiyeva, et al.

Selected by 31 July 2020

Yen-Chung Chen

Immunology

BTK operates a phospho-tyrosine switch to regulate NLRP3 inflammasome activity

Zsófia A. Bittner, Xiao Liu, Sangeetha Shankar, et al.

Selected by 14 July 2020

Louise Fraser

Immunology

Endogenous retroviruses are a source of enhancers with oncogenic potential in acute myeloid leukaemia

Özgen Deniz, Mamataz Ahmed, Christopher D. Todd, et al.

Selected by 21 April 2020

Jesus Victorino

Cancer Biology

Rapid discovery of synthetic DNA sequences to rewrite endogenous T cell circuits

Theodore L. Roth, P. Jonathan Li, Jasper F. Nies, et al.

Selected by 18 June 2019

Pavithran Ravindran

Bioengineering

Molecularly distinct models of zebrafish Myc-induced B cell leukemia

Chiara Borga, Clay Foster, Sowmya Iyer, et al.

Selected by 03 December 2018

Hannah Brunsdon

Cancer Biology

Systematic identification of human SNPs affecting regulatory element activity

Joris van Arensbergen, Ludo Pagie, Vincent FitzPatrick, et al.

Selected by 29 November 2018

Jesus Victorino

Genetically regulated human NODAL splice variants are differentially post-transcriptionally processed and functionally distinct

Scott D Findlay, Olena Bilyk, Kiefer Lypka, et al.

Selected by 03 April 2018

Pierre Osteil

Developmental Biology