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A high-coverage genome from a 200,000-year-old Denisovan

Stéphane Peyrégne, Diyendo Massilani, Yaniv Swiel, et al.

AND

A global map for introgressed structural variation and selection in humans

PingHsun Hsieh, Natthapon Soisangwan, David S. Gordon, et al.

Discussion

Human pluripotent stem cell-derived atrioventricular node-like pacemaker cells exhibit biological conduction bridge properties in vitro and in vivo

Michelle Lohbihler, Amos A. Lim, Stéphane Massé, et al.

Tandem duplication of serpin genes yields functional variation and snake venom inhibitors

Meilyn S. Ward, Matthew L. Holding, Laura M. Haynes, et al.

Discussion

Immune–tracheal intercellular signalling coordinates the muscle injury response in Drosophila

Nourhene Ammar, Olivier Josse, Aurélien Guillou, et al.

Malaria shaped human spatial organisation for the last 74 thousand years

Margherita Colucci, Michela Leonardi, James Blinkhorn, et al.

Identifying gaps between scientific and local knowledge in climate change adaptation for northern European agriculture

Kristina Blennow, Georg Carlsson, Laura Grenville-Briggs, et al.

Discussion

Succinate Dehydrogenase loss causes cascading metabolic effects that impair pyrimidine biosynthesis

Madeleine L. Hart, Kristian Davidsen, Serwah Danquah, et al.

Direct cell-to-cell transmission of retrotransposons

Maya Voichek, Andreas Bernhard, Maria Novatchkova, et al.

Discussion

Global coordination of protrusive forces in migrating immune cells

Patricia Reis-Rodrigues, Nikola Canigova, Mario J. Avellaneda, et al.

A long non-coding RNA at the cortex locus controls adaptive colouration in butterflies

Luca Livraghi, Joseph J. Hanly, Elizabeth Evans, et al.

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The ivory lncRNA regulates seasonal color patterns in buckeye butterflies

Richard A. Fandino, Noah K. Brady, Martik Chatterjee, et al.

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A micro-RNA drives a 100-million-year adaptive evolution of melanic patterns in butterflies and moths

Shen Tian, Tirtha Das Banerjee, Jocelyn Liang Qi Wee, et al.

Volumetric Compression Shifts Rho GTPase Balance and Induces Mechanobiological Cell State Transition

Xiangyu Gong, Ryan Nguyen, Zehua Chen, et al.

Caveola mechanotransduction reinforces the cortical cytoskeleton to promote epithelial resilience

John W. Brooks, Vikas Tillu, Suzie Verma, et al.