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Transcription repressor protein ZBTB25 interacts with HDAC1 in macrophages infected with Mycobacterium tuberculosis, and its inhibition leads to autophagy and killing of the intracellular pathogen

Aravind Madhavan, K B Arun, Akhil Raj Pushparajan, et al.

AND

Tamoxifen reduces inflammatory infiltration of neutrophils in the airways

Agustín Mansilla, Jaime Soto, Claudio Henríquez, et al.

Discussion

Human alveolar Type 2 epithelium transdifferentiates into metaplastic KRT5+ basal cells during alveolar repair

Jaymin J. Kathiriya, Chaoqun Wang, Alexis Brumwell, et al.

Organoid Easytag: an efficient workflow for gene targeting in human organoids

Dawei Sun, Lewis D. Evans, Emma L. Rawlins

An NKX2-1/ERK/WNT feedback loop modulates gastric identity and response to targeted therapy in lung adenocarcinoma

Rediet Zewdu, Elnaz Mirzaei Mehrabad, Kelley Ingram, et al.

Discussion

NINJA: an inducible genetic model for creating neoantigens in vivo

Martina Damo, Brittany Fitzgerald, Yisi Lu, et al.

Calpain-2 regulates hypoxia/HIF-induced amoeboid reprogramming and metastasis

Veronika te Boekhorst, Liying Jiang, Marius Mählen, et al.

Discussion

Axon-like protrusions promote small cell lung cancer migration and metastasis

Dian Yang, Fangfei Qu, Hongchen Cai, et al.

Discussion

Engineered probiotics for local tumor delivery of checkpoint blockade nanobodies

Candice Gurbatri, Courtney Coker, Taylor E. Hinchliffe, et al.

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Programmable bacteria induce durable tumor regression and systemic antitumor immunity

Sreyan Chowdhury, Taylor E Hinchliffe, Samuel Castro, et al.

Discussion

CXCR3-expressing metastasis-initiating cells induce and exploit a fibroblast niche in the lungs to fuel metastatic colonization

Maren Pein, Jacob Insua-Rodriguez, Jasmin Meier, et al.

Quantification of microenvironmental metabolites in murine cancer models reveals determinants of tumor nutrient availability

Mark R Sullivan, Laura V Danai, Caroline A Lewis, et al.

Applications of Machine Learning in Decision Analysis for Dose Management for Dofetilide

Andrew E Levy, Minakshi Biswas, Rachel Weber, et al.

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Optimal Scheduling of Bevacizumab and Pemetrexed/Cisplatin Dosing in Non-Small Cell lung cancer

Benjamin Schneider, Arnaud Boyer, Joseph Ciccolini, et al.

Discussion

Single-cell RNA sequencing reveals novel cell differentiation dynamics during human airway epithelium regeneration

Sandra Ruiz Garcia, Marie Deprez, Kevin Lebrigand, et al.