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4,5-dihydroxyhexanoic acid is a robust circulating and urine marker of mitochondrial disease and its severity

Owen S. Skinner, Maria Miranda, Fangcong Dong, et al.

Discussion

Oxidative stress triggers RNAPII arrest through PARylation and DNA damage

Quentin A. Thomas, Liyang Wu, Emma Lesage, et al.

Discussion

Human Assembloid model of Emergent Neurotropic Enteroviruses

Christine E. Peters, Jimena Andersen, Min-Yin Li, et al.

Discussion

Detergent-Triggered Membrane Remodelling Monitored via Intramembrane Fluorescence De-Quenching

Claudia M. F. Andrews, Christopher M. Hofmair, Lauryn Roberts, et al.

Discussion

Classical enhancers couple cis-regulatory logic with transcriptional condensates and 3D genome architecture

Ville Tiusanen, Divyesh Patel, Jihan Xia, et al.

Discussion

Small Molecule Agonists of TREM2 Reprogram Microglia and Protect Synapses in Human Alzheimer’s models

Hossam Nada, Shaoren Yuan, Farida El Gaamouch, et al.

Discussion

A thirty-year trend of increasing clinical orientation at the National Institutes of Health

Brad L. Busse, James M. Tucker, Summer E. Allen, et al.

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Prediction of transformative breakthroughs in biomedical research

Matthew T. Davis, Brad L. Busse, Salsabil Arabi, et al.

Discussion

Electrophysiological correlates of conscious experiences during sleep: Lucid dreams, sleep paralysis, out-of-body experiences, and false awakenings

Nerea L. Herrero, Yohann Corfdir, Aylin A. Vázquez-Chenlo, et al.

A drought stress-induced MYB transcription factor regulates pavement cell shape in leaves of European aspen (Populus tremula)

Sijia Liu, Siamsa M. Doyle, Kathryn M. Robinson, et al.

Resilience to cardiac aging in Greenland shark Somniosus microcephalus

Elena Chiavacci, Kirstine Fleng Steffensen, Pierre Delaroche, et al.

PPARδ activation in microglia drives a transcriptional response that primes phagocytic function while countering inflammatory activation

Jacob S. Deyell, Jonathan Hasselmann, Linda Stroud, et al.

Discussion

The lipidomic architecture of the mouse brain

Luca Fusar Bassini, Halima Hannah Schede, Laura Capolupo, et al.

Discussion