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4,5-dihydroxyhexanoic acid is a robust circulating and urine marker of mitochondrial disease and its severity

Owen S. Skinner, Maria Miranda, Fangcong Dong, et al.

Selected by 01 April 2026

Hannah Pletcher

Biochemistry

Small Molecule Agonists of TREM2 Reprogram Microglia and Protect Synapses in Human Alzheimer’s models

Hossam Nada, Shaoren Yuan, Farida El Gaamouch, et al.

Selected by 17 March 2026

Dina Kabbara

Pharmacology and Toxicology

PPARδ activation in microglia drives a transcriptional response that primes phagocytic function while countering inflammatory activation

Jacob S. Deyell, Jonathan Hasselmann, Linda Stroud, et al.

Selected by 11 February 2026

Isabel Paine

Neuroscience

The lipidomic architecture of the mouse brain

Luca Fusar Bassini, Halima Hannah Schede, Laura Capolupo, et al.

Selected by 09 February 2026

CRM UoE Journal Club et al.

Neuroscience

Active flows drive clustering and sorting of membrane components with differential affinity to dynamic actin cytoskeleton

Abrar Bhat, Amit Das, Meenakshi Iyer, et al.

Selected by 26 January 2026

Teodora Piskova

Biophysics

Gut microbial composition modulates food-specific CD4+ T cells in food allergy

Alexa R Weingarden, Flannery S Dahlberg, Caroline N Broude, et al.

Selected by 28 November 2025

Mitchell Sarmie, Serena Restori

Immunology

Aspartate transaminases are required for blood development

Narges Pourmandi, Greggory Myers, Arjun Jha, et al.

Selected by 26 November 2025

Hannah Pletcher

Biochemistry

Longitudinal single cell RNA-sequencing reveals evolution of micro- and macro-states in chronic myeloid leukemia

David E. Frankhouser, Dandan Zhao, Yu-Hsuan Fu, et al.

Selected by 03 November 2025

Charis Qi

Bioinformatics

Wide-ranging behavioral dysfunction in two mouse models of pathological human variants in the GRIK2 kainate receptor gene

Brynna T. Webb, Hieu Trinh, Emily A. Breach, et al.

Selected by 18 August 2025

Pushpinder Singh

Neuroscience

Capillary constrictions prime cancer cell tumorigenicity through PIEZO1

G. Silvani, C. Kopecky, S. Romanazzo, et al.

Selected by 03 August 2025

Sristilekha Nath

Cancer Biology

Leveraging autophagy and pyrimidine metabolism to target pancreatic cancer

Suzanne Dufresne, Ramya S Kuna, Kristiana Wong, et al.

Selected by 24 July 2025

Hannah Pletcher

Cancer Biology

FUS Mislocalization Rewires a Cortical Gene Network to Drive 2 Cognitive and Behavioral Impairment in ALS

Raphaelle CASSEL, Félicie LORENC, Aurélie BOMBARDIER, et al.

Selected by 14 July 2025

Taylor Stolberg

Neuroscience