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A direct experimental test of Ohno’s hypothesis

Ljiljana Mihajlovic, Bharat Ravi Iyengar, Florian Baier, et al.

Selected by 04 December 2023

Alejandra Herbert Leffler's Lab

Evolutionary Biology

Spastin locally amplifies microtubule dynamics to pattern the axon for presynaptic cargo delivery

Jayne Aiken, Erika L. F. Holzbaur

Selected by 04 December 2023

Matthew Davies

Cell Biology

Inference of drug off-target effects on cellular signaling using Interactome-Based Deep Learning

Nikolaos Meimetis, Douglas A. Lauffenburger, Avlant Nilsson

Selected by 29 November 2023

Benjamin Dominik Maier

Bioinformatics

The loss of DNA polymerase epsilon accessory subunits POLE3-POLE4 leads to BRCA1-independent PARP inhibitor sensitivity

Hasan Mamar, Roberta Fajka-Boja, Mónika Mórocz, et al.

Selected by 14 November 2023

Audrey Noireterre

Cancer Biology

Effects of Aerobic Exercise in Hepatic Lipid Droplet-Mitochondria interaction in Non-alcoholic Fatty Liver Disease

Juan Carlos Bórquez, Francisco Díaz-Castro, Francisco Pino-de La Fuente, et al.

Selected by 31 October 2023

Hellen Costa, Marcus Oliveira

Biochemistry

Competition and Synergy of Arp2/3 and Formins in Nucleating Actin Waves

Xiang Le Chua, Chee San Tong, X.J. Xŭ, et al.

Selected by 27 October 2023

Roberto Amadio

Cell Biology

Ancient origins of complex neuronal genes

Matthew J. McCoy, Andrew Z. Fire

Selected by 23 October 2023

Preethi Krishnaraj, Chee Kiang Ewe

Evolutionary Biology

Short N-terminal disordered regions and the proline-rich domain are major regulators of phase transitions for full-length UBQLN1, UBQLN2 and UBQLN4

Thuy P. Dao, Anitha Rajendran, Sarasi K. K. Galagedera, et al.

Selected by 22 October 2023

Aniruddha Das

Biochemistry

NAD+ metabolism is a key modulator of bacterial respiratory epithelial infections

Björn Klabunde, André Wesener, Wilhelm Bertrams, et al.

Selected by 17 October 2023

Matheus Atella de Oliveira, Marcus Oliveira

Immunology

NAD(H) homeostasis is essential for host protection mediated by glycolytic myeloid cells in tuberculosis

Hayden T. Pacl, Krishna C. Chinta, Vineel P. Reddy, et al.

Selected by 16 October 2023

Matheus Atella de Oliveira, Marcus Oliveira

Biochemistry

Glutamate helps unmask the differences in driving forces for phase separation versus clustering of FET family proteins in sub-saturated solutions

Mrityunjoy Kar, Laura T. Vogel, Gaurav Chauhan, et al.

Selected by 03 October 2023

Erich Sohn

Biochemistry

CRISPR-dependent base editing screens identify separation of function mutants of RADX with altered RAD51 regulatory activity

Madison B. Adolph, Atharv S. Garje, Swati Balakrishnan, et al.

Selected by 06 September 2023

Jessica Chevallier, Pierre Caron

Cell Biology