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Polθ is phosphorylated by Polo-like kinase 1 (PLK1) to enable repair of DNA double strand breaks in mitosis

Camille Gelot, Marton Tibor Kovacs, Simona Miron, et al.

Discussion

Biologically informed NeuralODEs for genome-wide regulatory dynamics

Intekhab Hossain, Viola Fanfani, John Quackenbush, et al.

Susceptible bacteria survive antibiotic treatment in the mammalian gastrointestinal tract without evolving resistance

Marinelle Rodrigues, Parastoo Sabaeifard, Muhammed Sadik Yildiz, et al.

EXO1-mediated DNA repair by single-strand annealing is essential for BRCA1-deficient cells

B. van de Kooij, A. Schreuder, R.S. Pavani, et al.

daf-42 is an evolutionarily young gene essential for dauer development in Caenorhabditis elegans

Daisy S. Lim, Jun Kim, Wonjoo Kim, et al.

SQ3370, the first clinical click chemistry-activated cancer therapeutic, shows safety in humans and translatability across species

Sangeetha Srinivasan, Nathan A. Yee, Michael Zakharian, et al.

Phosphorylation controls spatial and temporal activities of motor-PRC1 complexes to complete mitosis

Agata Gluszek-Kustusz, Benjamin Craske, Thibault Legal, et al.

Cell polarity linked to gravity sensing is generated by protein translocation from statoliths to the plasma membrane

Takeshi Nishimura, Shogo Mori, Hiromasa Shikata, et al.

AND

Amyloplast sedimentation repolarizes LAZYs to achieve gravity sensing in plants

Jiayue Chen, Renbo Yu, Na Li, et al.

Therapeutic strategy for spinal muscular atrophy by combining gene supplementation and genome editing

Fumiyuki Hatanaka, Keiichiro Suzuki, Kensaku Shojima, et al.

Discussion

Inhibition of Centrosome Clustering Reduces Cystogenesis and Improves Kidney Function in Autosomal Dominant Polycystic Kidney Disease

Tao Cheng, Aruljothi Mariappan, Ewa Langner, et al.

Massively parallel protein-protein interaction measurement by sequencing (MP3-seq) enables rapid screening of protein heterodimers

Alexander Baryshev, Alyssa La Fleur, Benjamin Groves, et al.

Laboratory evolution of flies to morphogen dosage via rapid maternal changes reveals predictable outcomes

Xueying C. Li, Lautaro Gandara, Måns Ekelöf, et al.