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Double-strand breaks in facultative heterochromatin require specific movements and chromatin changes for efficient repair

Marieke R. Wensveen, Aditya A. Dixit, Serafin U. Colmenares, et al.



Selected by Pierre Caron

Tardigrades dramatically upregulate DNA repair pathway genes in response to ionizing radiation

Courtney M. Clark-Hachtel, Jonathan D. Hibshman, Tristan De Buysscher, et al.



Selected by Isabella Cisneros

A transposase-derived gene required for human brain development

Luz Jubierre Zapater, Elias Rodriguez-Fos, Merce Planas-Felix, et al.



Selected by Amanda Ivanoff

Polθ is phosphorylated by Polo-like kinase 1 (PLK1) to enable repair of DNA double strand breaks in mitosis

Camille Gelot, Marton Tibor Kovacs, Simona Miron, et al.



Selected by Pierre Caron

Therapeutic strategy for spinal muscular atrophy by combining gene supplementation and genome editing

Fumiyuki Hatanaka, Keiichiro Suzuki, Kensaku Shojima, et al.



Selected by Preethi Krishnaraj

Pin1-promoted SUMOylation of RNF168 restrains its chromatin accumulation

Anoop Singh Chauhan, Alexander J. Garvin, Mohammed Jamshad, et al.



Selected by Pierre Caron

Drag-and-drop genome insertion without DNA cleavage with CRISPR-directed integrases

Eleonora I. Ioannidi, Matthew T. N. Yarnall, Cian Schmitt-Ulms, et al.



Selected by Louise Moyle et al.

Saturation variant interpretation using CRISPR prime editing

Steven Erwood, Teija M.I. Bily, Jason Lequyer, et al.



Selected by Jeffrey Calhoun

EccDNA formation is dependent on MMEJ, repressed by c-nhej pathway, and stimulated by DNA double-strand break

Teressa Paulsen, Pumoli Malapati, Rebeka Eki, et al.



Selected by Sree Rama Chaitanya

Severe immunodeficiency in mice lacking DNA repair factors XLF and Mri

Sergio Castañeda-Zegarra, Qindong Zhang, Amin Alirezaylavasani, et al.



Selected by Jennifer Ann Black

Hyperactive end joining repair mediates resistance to DNA damaging therapy in p53-deficient cells

Rashmi J. Kumar, Hui Xiao Chao, Victoria R. Roberts, et al.



Selected by Matthew Burke

Impact of chromatin context on Cas9-induced DNA double-strand break repair pathway balance

Ruben Schep, Eva Brinkman, Christ Leemans, et al.



Selected by Katie Weiner

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