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Comprehensive Lineage Tracing Maps the Landscape of Cell Fate Decisions in Mouse Embryogenesis

William N. Colgan, Luke W. Koblan, JoAnne Villagrana, et al.

Discussion

Combinatorial and Inducible CRISPRa/i Enables Canalized hiPSC Forward Programming and Iterative Refinement via Single-Cell Genomics

Federica Sozza, Alberto Romano, Nicole D’Elia, et al.

Fear conditioning biases olfactory sensory neuron frequencies across generations

Clara W. Liff, Yasmine R. Ayman, Eliza C.B. Jaeger, et al.

Discussion

Temporal degradation of PRC2 uncovers specific developmental dependencies

Ming-Kang Lee, Sebastian D. Mackowiak, Daniel Felismino, et al.

Exogenous Amyloid Sequences: Their Role in Amyloid-Beta Heterotypic Aggregation

Jofre Seira Curto, Sandra Villegas, Maria Rosario Fernandez, et al.

Discussion

Human Assembloid Model of Emergent Neurotropic Enteroviruses

Christine E. Peters, Jimena Andersen, Min-Yin Li, et al.

Discussion

Small Molecule Agonists of TREM2 Reprogram Microglia and Protect Synapses in Human Alzheimer’s models

Hossam Nada, Shaoren Yuan, Farida El Gaamouch, et al.

A thirty-year trend of increasing clinical orientation at the National Institutes of Health

Brad L. Busse, James M. Tucker, Summer E. Allen, et al.

AND

Prediction of transformative breakthroughs in biomedical research

Matthew T. Davis, Brad L. Busse, Salsabil Arabi, et al.

The lipidomic architecture of the mouse brain

Luca Fusar Bassini, Halima Hannah Schede, Laura Capolupo, et al.

Discussion

Active flows drive clustering and sorting of membrane components with differential affinity to dynamic actin cytoskeleton

Abrar Bhat, Amit Das, Meenakshi Iyer, et al.

Human pluripotent stem cell-derived macrophages modify development of human kidney organoids

Filipa M. Lopes, Ioannis Bantounas, Alexandra Sarov, et al.

Junctional Heterogeneity Shapes Epithelial Morphospace

Anubhav Prakash, Raman Kaushik, Nishant Singh, et al.