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The WD and linker domains of ATG16L1 required for non-canonical autophagy limit lethal influenza A virus infection at epithelial surfaces

Yingxue Wang, Weijiao Zhang, Matthew Jefferson, et al.

Selected by 09 March 2020

Kirsty Hooper

Cell Biology

Combining antibiotics with antivirulence compounds is effective and can reverse selection for antibiotic resistance in Pseudomonas aeruginosa

Chiara Rezzoagli, Martina Archetti, Michael Baumgartner, et al.

Selected by 10 December 2019

Zhang-He Goh

Pharmacology and Toxicology

Origin and microenvironment contribute to the sexually dimorphic phenotype and function of peritoneal macrophages

Calum C. Bain, Douglas A. Gibson, Nicholas Steers, et al.

Selected by 03 December 2019

Connor Rosen

Immunology

Lis1 regulates Phagocytosis by co-localising with actin in the Phagocytic cup

Aditya Chhatre, Paulomi Sanghavi, Roop Mallik

Selected by 19 November 2019

Nicola Stevenson

Cell Biology

Hif-1alpha stabilisation is protective against infection in a zebrafish model of comorbidity

Yves Schild, Abdirizak Mohamed, Edward J. Wootton, et al.

Selected by 28 October 2019

Jonny Coates

Immunology

Single-cell RNA-sequencing reveals profibrotic roles of distinct epithelial and mesenchymal lineages in pulmonary fibrosis

Arun C. Habermann, Austin J. Gutierrez, Linh T. Bui, et al.

AND

Single Cell RNA-seq reveals ectopic and aberrant lung resident cell populations in Idiopathic Pulmonary Fibrosis

Taylor S. Adams, Jonas C. Schupp, Sergio Poli, et al.

Selected by 20 September 2019

Rob Hynds

Cell Biology

Engineering Phage Host-Range and Suppressing Bacterial Resistance Through Phage Tail Fiber Mutagenesis

Kevin Yehl, Sébastien Lemire, Andrew C. Yang, et al.

Selected by 27 July 2019

Zhang-He Goh

Synthetic Biology

Integrated Metabolomic and Transcriptomic Profiling Reveals Novel Activation-Induced Metabolic Networks in Human T cells

S. Hiemer, S. Jatav, J. Jussif, et al.

Selected by 21 June 2019

Jonny Coates

Immunology

Engineered probiotics for local tumor delivery of checkpoint blockade nanobodies

Candice Gurbatri, Courtney Coker, Taylor E. Hinchliffe, et al.

AND

Programmable bacteria induce durable tumor regression and systemic antitumor immunity

Sreyan Chowdhury, Taylor E Hinchliffe, Samuel Castro, et al.

Selected by 09 May 2019

Pavithran Ravindran

Bioengineering

Myc instructs and maintains pancreatic adenocarcinoma phenotype

Nicole M Sodir, Roderik M Kortlever, Valentin JA Barthet, et al.

Selected by 08 March 2019

William Hill

Cancer Biology

Fragment-based discovery of a new class of inhibitors targeting mycobacterial tRNA modification

Sherine E. Thomas, Andrew J. Whitehouse, Karen Brown, et al.

Selected by 05 March 2019

Yasmin Lau

SLC19A1 is a cyclic dinucleotide transporter

Rutger Luteijn, Shivam Zaver, Benjamin G Gowen, et al.

AND

SLC19A1 is an importer of the immunotransmitter cGAMP

Anthony F. Cordova, Christopher Ritchie, Gaelen T. Hess, et al.

AND

2'3'-cGAMP is an immunotransmitter produced by cancer cells and regulated by ENPP1

Jacqueline A Carozza, Volker Boehnert, Kelsey E Shaw, et al.

Selected by 13 February 2019

Connor Rosen

Immunology