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The loss of DNA polymerase epsilon accessory subunits POLE3-POLE4 leads to BRCA1-independent PARP inhibitor sensitivity

Hasan Mamar, Roberta Fajka-Boja, Mónika Mórocz, et al.

Selected by Audrey Noireterre

NAD+ metabolism is a key modulator of bacterial respiratory epithelial infections

Björn Klabunde, André Wesener, Wilhelm Bertrams, et al.

Selected by Matheus Atella de Oliveira, Marcus Oliveira

Glutamate helps unmask the differences in driving forces for phase separation versus clustering of FET family proteins in sub-saturated solutions

Mrityunjoy Kar, Laura T. Vogel, Gaurav Chauhan, et al.

Selected by Erich Sohn

Polθ is phosphorylated by Polo-like kinase 1 (PLK1) to enable repair of DNA double strand breaks in mitosis

Camille Gelot, Marton Tibor Kovacs, Simona Miron, et al.

Selected by Pierre Caron

Alumni

Mitotic heritability of DNA methylation at intermediately methylated sites is imprecise

Amir D. Hay, Noah J. Kessler, Daniel Gebert, et al.

Selected by Samantha Seah et al.

Single-strand mismatch and damage patterns revealed by single-molecule DNA sequencing

Mei Hong Liu, Benjamin Costa, Una Choi, et al.

Selected by Kerryn Elliott

Transcriptional units form the elementary constraining building blocks of the bacterial chromosome

Amaury Bignaud, Charlotte Cockram, Eric Allemand, et al.

Selected by Jennifer Ann Black

ATM-dependent formation of a novel chromatin compartment regulates the Response to DNA Double Strand Breaks and the biogenesis of translocations

Coline Arnould, Vincent Rocher, Aldo S. Bader, et al.

Selected by Jennifer Ann Black

cGAS recruitment to micronuclei is dictated by pre-existing nuclear chromatin status

Kate M. MacDonald, Shirony Nicholson-Puthenveedu, Maha M. Tageldein, et al.

Selected by Roberto Amadio

Drag-and-drop genome insertion without DNA cleavage with CRISPR-directed integrases

Eleonora I. Ioannidi, Matthew T. N. Yarnall, Cian Schmitt-Ulms, et al.

Selected by Louise Moyle et al.

CDK9 and PP2A regulate the link between RNA polymerase II transcription termination and RNA maturation

Michael Tellier, Justyna Zaborowska, Jonathan Neve, et al.

Selected by Isabella Maudlin

Lightning Fast and Highly Sensitive Full-Length Single-cell sequencing using FLASH-Seq

Vincent Hahaut, Dinko Pavlinic, Cameron Cowan, et al.

Selected by Jennifer Ann Black