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A High Content Screen for Mucin-1-Reducing Compounds Identifies Fostamatinib as a Candidate for Rapid Repurposing for Acute Lung Injury during the COVID-19 pandemic

Maria Alimova, Eriene-Heidi Sidhom, Abhigyan Satyam, et al.

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Anti-SARS-CoV-2 IgG from severely ill COVID-19 patients promotes macrophage hyper-inflammatory responses

Willianne Hoepel, Hung-Jen Chen, Sona Allahverdiyeva, et al.

Discussion

Transcription repressor protein ZBTB25 interacts with HDAC1 in macrophages infected with Mycobacterium tuberculosis, and its inhibition leads to autophagy and killing of the intracellular pathogen

Aravind Madhavan, K B Arun, Akhil Raj Pushparajan, et al.

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Tamoxifen reduces inflammatory infiltration of neutrophils in the airways

Agustín Mansilla, Jaime Soto, Claudio Henríquez, et al.

Discussion

A systematic examination of preprint platforms for use in the medical and biomedical sciences setting

Jamie J Kirkham, Naomi Penfold, Fiona Murphy, et al.

Systematic analysis of protein targets associated with adverse events of drugs from clinical trials and post-marketing reports

Ines A. Smit, Avid M. Afzal, Chad H. G. Allen, et al.

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Toward in vivo-relevant hERG safety assessment and mitigation strategies based on relationships between non-equilibrium blocker binding, three-dimensional channel-blocker interactions, dynamic occupancy, dynamic exposure, and cellular arrhythmia

Hongbin Wan, Gianluca Selvaggio, Robert A. Pearlstein

Discussion

Rational Design of Minimal Synthetic Promoters for Plants

Yaomin Cai, Kalyani Kallam, Henry Tidd, et al.

Anti-biofilm efficacy of a medieval treatment for bacterial infection requires the combination of multiple ingredients

Jessica Furner-Pardoe, Blessing O Anonye, Ricky Cain, et al.

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The safety profile of Bald’s eyesalve for the treatment of bacterial infections

Blessing O Anonye, Valentine Nweke, Jessica Furner-Pardoe, et al.

Live-cell 3D single-molecule tracking reveals how NuRD modulates enhancer dynamics

S Basu, O Shukron, A Ponjavic, et al.

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Live-cell single particle tracking of PRC1 reveals a highly dynamic system with low target site occupancy

Miles K. Huseyin, Robert J. Klose

BiteOscope: an open platform to study mosquito blood-feeding behavior

Felix JH Hol, Louis Lambrechts, Manu Prakash

CeMbio - The C. elegans microbiome resource

Philipp Dirksen, Adrien Assié, Johannes Zimmermann, et al.

The mitotic protein NuMA plays a spindle-independent role in nuclear formation and mechanics

Andrea Serra-Marques, Ronja Houtekamer, Dorine Hintzen, et al.

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NuMA interaction with chromatin is vital for proper nuclear architecture in human cells

Ashwathi Rajeevan, Riya Keshri, Sachin Kotak

Mutual Potentiation of Plant Immunity by Cell-surface and Intracellular Receptors

Bruno Pok Man Ngou, Hee-Kyung Ahn, Pingtao Ding, et al.

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Pattern-recognition receptors are required for NLR-mediated plant immunity

Minhang Yuan, Zeyu Jiang, Guozhi Bi, et al.

Early neurulation recapitulated in assemblies of embryonic and extraembryonic cells

Noémie M. L. P. Bérenger-Currias, Maria Mircea, Esmée Adegeest, et al.