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Alzheimer’s Disease Patient Brain Extracts Induce Multiple Pathologies in Vascularized Neuroimmune Organoids for Disease Modeling and Drug Discovery

Yanru Ji, Xiaoling Chen, Meek Connor Joseph, et al.

HIF1A contributes to the survival of aneuploid and mosaic pre-implantation embryos

Estefania Sanchez-Vasquez, Marianne E. Bronner, Magdalena Zernicka-Goetz

Lineage-specific CDK activity dynamics characterize early mammalian development

Bechara Saykali, Andy D. Tran, James A. Cornwell, et al.

Actin polymerization drives lumen formation in a human epiblast model

Dhiraj Indana, Andrei Zakharov, Youngbin Lim, et al.

A tension-induced morphological transition shapes the avian extra-embryonic territory

Arthur Michaut, Alexander Chamolly, Aurélien Villedieu, et al.

Discussion

Stem cell-derived mouse embryos develop within an extra-embryonic yolk sac to form anterior brain regions and a beating heart

Gianluca Amadei, Charlotte E Handford, Joachim De Jonghe, et al.

AND

Mouse-embryo model derived exclusively from embryonic stem cells undergo neurulation and heart development

Kasey Y.C. Lau, Hernan Rubinstein, Carlos W. Gantner, et al.

Isolation disrupts social interactions and destabilizes brain development in bumblebees

Z Yan Wang, Grace C. McKenzie-Smith, Weijie Liu, et al.

Discussion

Pseudo-dynamic analysis of heart tube formation in the mouse reveals strong regional variability and early left-right asymmetry

Isaac Esteban, Patrick Schmidt, Susana Temiño, et al.

Rapid redistribution and extensive binding of NANOG and GATA6 at shared regulatory elements underlie specification of divergent cell fates

Joyce J. Thompson, Daniel J. Lee, Apratim Mitra, et al.

Extracellular mechanical forces drive endocardial cell volume decrease during cardiac valve morphogenesis

Hélène Vignes, Christina Vagena-Pantoula, Mangal Prakash, et al.

Semaphorin3f as an intrinsic regulator of chamber-specific heart development

R Halabi, P.B. Cechmanek, C.L. Hehr, et al.

Discussion

YAP1 Regulates the Self-organized Fate Patterning of hESCs-Derived Gastruloids

Servando Giraldez, Eleonora Stronati, Ling Huang, et al.

Discussion