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Tau assemblies enter the cytosol of neurons in a cholesterol sensitive manner

Benjamin J. Tuck, Taxiarchis Katsinelos, Lauren V. C. Miller, et al.

Selected by 07 July 2021

Emma Wilson

Neuroscience

Foldamers Reveal and Validate Novel Therapeutic Targets Associated with Toxic α-Synuclein Self-Assembly

Jemil Ahmed, Tessa C. Fitch, Courtney M. Donnelly, et al.

Selected by 05 June 2021

Joanna Zell

Biochemistry

Cytosolic aggregation of mitochondrial proteins disrupts cellular homeostasis by stimulating other proteins aggregation

Urszula Nowicka, Piotr Chroscicki, Karen Stroobants, et al.

Selected by 20 May 2021

Eric McGregor

Cell Biology

A “spindle and thread”-mechanism unblocks translation of N-terminally disordered proteins

Margit Kaldmäe, Thibault Vosselman, Xueying Zhong, et al.

Selected by 16 April 2021

Utrecht protein Folding and Assembly

Biochemistry

Selectivity of protein Interactions along the aggregation Pathway of α-Synuclein

André D. G. Leitão, Paulina Rudolffi Soto, Alexandre Chappard, et al.

Selected by 15 April 2021

Utrecht protein Folding and Assembly

Biochemistry

Suppression of aggregate and amyloid formation by a novel intrinsically disordered region in metazoan Hsp110 chaperones

Unekwu M. Yakubu, Kevin A. Morano

Selected by 14 April 2021

Utrecht protein Folding and Assembly

Biochemistry

A copper chaperone-mimetic polytherapy for SOD1-associated amyotrophic lateral sclerosis

McAlary L., Shephard V.K., Wright G.S.A., et al.

Selected by 09 April 2021

Utrecht protein Folding and Assembly

Biochemistry

Brain deletion of Serf2 shifts amyloid conformation in a mouse model

E. Stroo, L. Janssen, O. Sin, et al.

Selected by 06 April 2021

Utrecht protein Folding and Assembly

Molecular Biology

Microglia become hypofunctional and release metalloproteases and tau seeds after phagocytosing live neurons with P301S tau aggregates

Jack H. Brelstaff, Matthew Mason, Taxiarchis Katsinelos, et al.

Selected by 11 March 2021

Kristina Kuhbandner

Neuroscience

Investigating receptor-mediated antibody transcytosis using Blood-Brain Barrier organoid arrays

Claire Simonneau, Martina Duschmalé, Alina Gavrilov, et al.

Selected by 20 February 2021

Kristina Kuhbandner

Cell Biology

Poly-ADP-ribosylation drives loss of protein homeostasis in ATM and Mre11 deficiency

Ji-Hoon Lee, Seung W. Ryu, Nicolette A. Ender, et al.

Selected by 13 November 2020

Sree Rama Chaitanya

Biochemistry

CSPα reduces aggregates and rescues striatal dopamine release in αsynuclein transgenic mice

L Caló, E Hidari, M Wegrzynowicz, et al.

Selected by 21 August 2020

Kristina Kuhbandner

Neuroscience