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Skd3 (human CLPB) is a potent mitochondrial protein disaggregase that is inactivated by 3-methylglutaconic aciduria-linked mutations

Ryan R. Cupo, James Shorter

Selected by Tessa Sinnige

Synaptogenic activity of the axon guidance molecule Robo2 is critical for hippocampal circuit function

Heike Blockus, Sebastian V. Rolotti, Miklos Szoboszlay, et al.

Selected by Ana Dorrego-Rivas

Selective K-ATP channel-dependent loss of pacemaking in vulnerable nigrostriatal dopamine neurons by α-synuclein aggregates

Poonam Thakur, Kelvin Luk, Jochen Roeper

Selected by Jessica Xie

HSP110 dependent HSP70 disaggregation machinery mediates prion-like propagation of amyloidogenic proteins in metazoa

Jessica Tittelmeier, Carl Alexander Sandhof, Heidrun Maja Ries, et al.

Selected by Tessa Sinnige

The properties of α-synuclein secondary nuclei are dominated by the solution conditions rather than the seed fibril strain

Alessia Peduzzo, Sara Linse, Alexander K. Buell

Selected by Tessa Sinnige

Small molecules for modulating protein driven liquid-liquid phase separation in treating neurodegenerative disease

Richard J. Wheeler, Hyun O. Lee, Ina Poser, et al.

Selected by Madhuja Samaddar

Negative Regulation of Autophagy by UBA6-BIRC6–Mediated Ubiquitination of LC3

Rui Jia, Juan S. Bonifacino

Selected by Sandra Malmgren Hill

Elucidating the molecular determinants of Aβ aggregation with deep mutational scanning

Vanessa E Gray, Katherine Sitko, Floriane Z. Ngako Kameni, et al.

Selected by Suzanne McDermott

Spontaneous isomerization of long-lived proteins provides a molecular mechanism for the lysosomal failure observed in Alzheimer’s disease

Tyler R. Lambeth, Dylan L. Riggs, Lance E. Talbert, et al.

Selected by Joanna Cross

Microfluidic protein isolation and sample preparation for high resolution cryo-EM

Claudio Schmidli, Stefan Albiez, Luca Rima, et al.

Selected by David Wright

Phase transition and amyloid formation by a viral protein as an additional molecular mechanism of virus-induced cell toxicity

Edoardo Salladini, Claire Debarnot, Vincent Delauzun, et al.

Selected by Tessa Sinnige

A non-canonical arm of UPR^ER mediates longevity through ER remodeling and lipophagy.

Joseph R Daniele, Ryo Higuchi-Sanabria, Vidhya Ramachandran, et al.

Selected by Sandra Franco Iborra