Search results

CRISPR screens in iPSC-derived neurons reveal principles of tau proteostasis

Avi J. Samelson, Nabeela Ariqat, Justin McKetney, et al.

Selected by Kritika Mehta

ProteasomeID: quantitative mapping of proteasome interactomes and substrates for in vitro and in vivo studies

Aleksandar Bartolome, Julia C. Heiby, Therese Dau, et al.

Selected by Aniruddha Das

Olfactory chemosensation extends lifespan through TGF-β signaling and UPR activation

Evandro A. De-Souza, Maximillian A. Thompson, Rebecca C. Taylor

Selected by Chee Kiang Ewe

Cytosolic aggregation of mitochondrial proteins disrupts cellular homeostasis by stimulating other proteins aggregation

Urszula Nowicka, Piotr Chroscicki, Karen Stroobants, et al.

Selected by Eric McGregor

Interspecies differences in proteome turnover kinetics are correlated with lifespans and energetic demands

Kyle Swovick, Denis Firsanov, Kevin A. Welle, et al.

Selected by Teresa Rayon

Changing and stable chromatin accessibility supports transcriptional overhaul during neural stem cell activation

Sun Y. Maybury-Lewis, Abigail K. Brown, Mitchell Yeary, et al.

Selected by Kirsty Ferguson

Yeast FIT2 homolog is necessary to maintain cellular proteostasis by regulating lipid homeostasis

Peter Shyu, Wei Sheng Yap, Maria L. Gaspar, et al.

Selected by Madhuja Samaddar

Quantitative analysis of the ubiquitin-proteasome system under proteolytic and folding stressors

Jeremy J. Work, Onn Brandmann

Selected by Sandra Malmgren Hill

Aging is associated with a systemic length-driven transcriptome imbalance

Thomas Stoeger, Rogan A. Grant, Alexandra C. McQuattie-Pimentel, et al.

Selected by Monika S. Magon

LTK is an ER-resident receptor tyrosine kinase that regulates secretion

Federica G. Centonze, Veronika Reiterer, Karsten Nalbach, et al.

Selected by Nicola Stevenson

A non-canonical arm of UPR^ER mediates longevity through ER remodeling and lipophagy.

Joseph R Daniele, Ryo Higuchi-Sanabria, Vidhya Ramachandran, et al.

Selected by Sandra Franco Iborra

A non-canonical arm of UPR^ER mediates longevity through ER remodeling and lipophagy.

Joseph R Daniele, Ryo Higuchi-Sanabria, Vidhya Ramachandran, et al.

Selected by Sandra Malmgren Hill