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The chromatin, topological and regulatory properties of pluripotency-associated poised enhancers are conserved in vivo

Giuliano Crispatzu, Rizwan Rehimi, Tomas Pachano, et al.

Selected by 17 February 2021

Sergio Menchero

Molecular Biology

Smad3 Regulates Smooth Muscle Cell Fate and Governs Adverse Remodeling and Calcification of Atherosclerotic Plaque

Paul Cheng, Robert C. Wirka, Juyong Brian Kim, et al.

Selected by 12 January 2021

Debbie Ho

Cell Biology

Association analysis of repetitive elements and R-loop formation across species

Chao Zeng, Masahiro Onoguchi, Michiaki Hamada

Selected by 28 December 2020

Sree Rama Chaitanya

Genomics

Evolution of mouse circadian enhancers from transposable elements

Julius Judd, Hayley Sanderson, Cédric Feschotte

Selected by 15 December 2020

Miguel V. Almeida

Genomics

The hourglass model of evolutionary conservation during embryogenesis extends to developmental enhancers with signatures of positive selection

Jialin Liu, Rebecca R. Viales, Pierre Khoueiry, et al.

Selected by 11 December 2020

Irepan Salvador-Martinez

Bioinformatics

CENP-A chromatin prevents replication stress at centromeres to avoid structural aneuploidy

Simona Giunta, Solène Hervé, Ryan R. White, et al.

Selected by 10 December 2020

Sree Rama Chaitanya

Cell Biology

Live-cell imaging shows uneven segregation of extrachromosomal DNA elements and transcriptionally active extrachromosomal DNA clusters in cancer

Eunhee Yi, Amit D. Gujar, Molly Guthrie, et al.

Selected by 28 October 2020

Sree Rama Chaitanya

Cancer Biology

Genome-wide maps of enhancer regulation connect risk variants to disease genes

Joseph Nasser, Drew T. Bergman, Charles P. Fulco, et al.

Selected by 30 September 2020

Jesus Victorino

Genomics

Epigenetic conflict on a degenerating Y chromosome increases mutational burden in Drosophila males

Kevin H.-C. Wei, Lauren Gibilisco, Doris Bachtrog

Selected by 16 September 2020

Hann Ng

Developmental Biology

Orphan CpG islands boost the regulatory activity of poised enhancers and dictate the responsiveness of their target genes

Tomás Pachano, Víctor Sánchez-Gaya, María Mariner-Faulí, et al.

Selected by 07 September 2020

Jesus Victorino

Genetics

Upregulation and cell specificity of C4 genes are derived from ancestral C3 gene regulatory networks

Pallavi Singh, Sean R. Stevenson, Ivan Reyna-Llorens, et al.

Selected by 30 July 2020

Ying Sun

Plant Biology

CTCF Mediates Dosage and Sequence-context-dependent Transcriptional Insulation through Formation of Local Chromatin Domains

Hui Huang, Quan Zhu, Adam Jussila, et al.

Selected by 25 July 2020

Clarice Hong

Genetics