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The loss of DNA polymerase epsilon accessory subunits POLE3-POLE4 leads to BRCA1-independent PARP inhibitor sensitivity

Hasan Mamar, Roberta Fajka-Boja, Mónika Mórocz, et al.

Selected by 14 November 2023

Audrey Noireterre

Cancer Biology

CRISPR-dependent base editing screens identify separation of function mutants of RADX with altered RAD51 regulatory activity

Madison B. Adolph, Atharv S. Garje, Swati Balakrishnan, et al.

Selected by 06 September 2023

Jessica Chevallier, Pierre Caron

Cell Biology

EXO1-mediated DNA repair by single-strand annealing is essential for BRCA1-deficient cells

B. van de Kooij, A. Schreuder, R.S. Pavani, et al.

Selected by 15 May 2023

Jennifer Ann Black

Molecular Biology

Actin nucleators safeguard replication forks by limiting nascent strand degradation

Jadwiga Nieminuszczy, Peter R. Martin, Ronan Broderick, et al.

Selected by 22 March 2023

Roberto Amadio

Cell Biology

BRCA1/BARD1 ubiquitinates PCNA in unperturbed conditions to promote replication fork stability and continuous DNA synthesis

Daniel Salas-Lloret, Néstor García-Rodríguez, Lisanne Giebel, et al.

Selected by 09 March 2023

Pierre Caron

Cancer Biology

Nuclear myosin VI maintains replication fork stability

Jie Shi, Kristine Hauschulte, Ivan Mikicic, et al.

Selected by 13 December 2022

Pierre Caron

Molecular Biology

CENP-A chromatin prevents replication stress at centromeres to avoid structural aneuploidy

Simona Giunta, Solène Hervé, Ryan R. White, et al.

Selected by 10 December 2020

Sree Rama Chaitanya

Cell Biology

ARID1A regulates R-loop associated DNA replication stress

Shuhe Tsai, Emily Yun-Chia Chang, Louis-Alexandre Fournier, et al.

Selected by 05 December 2020

Sree Rama Chaitanya

Molecular Biology

Single-molecule live cell imaging of the Smc5/6 DNA repair complex

Thomas J. Etheridge, Desiree Villahermosa, Anja Irmisch, et al.

Selected by 26 June 2020

Jennifer Ann Black

Molecular Biology

RADX Sustains POT1 Function at Telomeres to Counteract RAD51 Binding, which Triggers Telomere Fragility

Anna-Sophia Briod, Galina Glousker, Joachim Lingner

Selected by 25 June 2020

Upasana Roy

Cell Biology

fork-seq: replication landscape of the Saccharomyces cerevisiae genome by nanopore sequencing

Magali Hennion, Jean-Michel Arbona, Laurent Lacroix, et al.

Selected by 27 April 2020

Jennifer Ann Black

Genomics

Mutational signatures are jointly shaped by DNA damage and repair

Nadezda V Volkova, Bettina Meier, Víctor González-Huici, et al.

Selected by 24 February 2020

Kerryn Elliott

Cancer Biology