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Stem cell-derived mouse embryos develop within an extra-embryonic yolk sac to form anterior brain regions and a beating heart

Gianluca Amadei, Charlotte E Handford, Joachim De Jonghe, et al.

AND

Mouse-embryo model derived exclusively from embryonic stem cells undergo neurulation and heart development

Kasey Y.C. Lau, Hernan Rubinstein, Carlos W. Gantner, et al.

Comparative developmental genomics of sex-biased gene expression in early embryogenesis across mammals

Victorya Richardson, Kai Zhang, Nora Engel, et al.

Synthetic memory circuits for programmable cell reconfiguration in plants

James P B Lloyd, Florence Ly, Patrick Gong, et al.

AND

Synthetic genetic circuits enable reprogramming of plant roots

Jennifer A. N. Brophy, Katie J. Magallon, Kiril Kniazev, et al.

Developmentally programmed epigenome regulates cellular plasticity at the parental-to-zygote transition

Ryan J. Gleason, Christopher S. Semancik, Gitanjali Lakshminarayanan, et al.

Discussion

Hedgehog signaling can enhance glycolytic ATP production in the Drosophila wing disc

Ioannis Nellas, K. Venkatesan Iyer, Juan M. Iglesias-Artola, et al.

Single-cell transcriptome analysis of embryonic and adult endothelial cells allows to rank the hemogenic potential of post-natal endothelium

Artem Adamov, Yasmin Natalia Serina Secanechia, Christophe Lancrin

Diverse mechanisms for epigenetic imprinting in mammals

Daniel Andergassen, Zachary D. Smith, John L. Rinn, et al.

Discussion

A genome-wide knock-out screen for actors of epigenetic silencing reveals new regulators of germline genes and 2-cell like cell state

Nikhil Gupta, Lounis Yakhou, Julien Richard Albert, et al.

Aerobic glycolysis is important for zebrafish larval wound closure and tail regeneration

Claire A. Scott, Tom J. Carney, Enrique Amaya

Generative modeling of single-cell population time series for inferring cell differentiation landscapes

Grace H.T. Yeo, Sachit D. Saksena, David K. Gifford

Discussion

Human skeletal muscle CD90⁺ fibro-adipogenic progenitors are associated with muscle degeneration in type 2 diabetic patients

Jean Farup, Jesper Just, Frank de Paoli, et al.

The deubiquitinase Usp9x regulates PRC2-mediated chromatin reprogramming during mouse development

Trisha A. Macrae, Miguel Ramalho-Santos