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Targeting RhoA activity rejuvenates aged hematopoietic stem cells

Eva Mejía-Ramírez, Pablo Iañez Picazo, Barbara Walter, et al.

Tumor-infiltrating CD27^-IgD^- regulatory B cells suppress cytotoxic CD8⁺T cell responses in renal cell carcinoma

Zara Baig, Isabella Withnell, Joseph C.F. Ng, et al.

An immunomechanical checkpoint PYK2 governs monocyte-to-macrophage differentiation in pancreatic cancer

Wenyan Xie, Xin Yu, Qingxin Yang, et al.

Discussion

tRNA synthetase activity is required for stress granule and P-body assembly

Max Baymiller, Noah S. Helton, Benjamin Dodd, et al.

Discussion

Adult caudal fin shape is imprinted in the embryonic fin fold

Eric Surette, Joan Donahue, Stephanie Robinson, et al.

Fetal brain response to maternal inflammation requires microglia

Bridget Elaine LaMonica Ostrem, Nuria Dominguez Iturza, Jeffrey Stogsdill, et al.

Discussion

OGT prevents DNA demethylation and suppresses the expression of transposable elements in heterochromatin by restraining TET activity genome-wide

Hugo Sepulveda, Xiang Li, Xiaojing Yue, et al.

Discussion

Scalable and efficient generation of mouse primordial germ cell-like cells

Xinbao Ding, Liangdao Li, Jingyi Gao, et al.

Prenatal inflammation reprograms hyperactive ILC2s that promote allergic lung inflammation and airway dysfunction

Diego A. López, Aleah Griffin, Lorena Moreno Aguilar, et al.

Discussion

Volumetric Compression Shifts Rho GTPase Balance and Induces Mechanobiological Cell State Transition

Xiangyu Gong, Ryan Nguyen, Zehua Chen, et al.

Mitochondrial citrate carrier SLC25A1 is a dosage-dependent regulator of metabolic reprogramming and morphogenesis in the developing heart

Chiemela Ohanele, Jessica N. Peoples, Anja Karlstaedt, et al.

Discussion

Stem cell-derived mouse embryos develop within an extra-embryonic yolk sac to form anterior brain regions and a beating heart

Gianluca Amadei, Charlotte E Handford, Joachim De Jonghe, et al.

AND

Mouse-embryo model derived exclusively from embryonic stem cells undergo neurulation and heart development

Kasey Y.C. Lau, Hernan Rubinstein, Carlos W. Gantner, et al.