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Preprint Peer Review – Biochemistry Course at UFRJ, Brazil

Communication of scientific knowledge has changed dramatically in recent decades and the public perception of scientific discoveries depends on the peer review process of articles published in scientific journals. Preprints are key vehicles for the dissemination of scientific discoveries, but they are still not properly recognized by the scientific community since peer review is very limited. On the other hand, peer review is very heterogeneous and a fundamental aspect to improve it is to train young scientists on how to think critically and how to evaluate scientific knowledge in a professional way. Thus, this course aims to: i) train students on how to perform peer review of scientific manuscripts in a professional manner; ii) develop students' critical thinking; iii) contribute to the appreciation of preprints as important vehicles for the dissemination of scientific knowledge without restrictions; iv) contribute to the development of students' curricula, as their opinions will be published and indexed on the preLights platform. The evaluations will be based on qualitative analyses of the oral presentations of preprints in the field of biochemistry deposited in the bioRxiv server, of the critical reports written by the students, as well as of the participation of the students during the preprints discussions.

List by Marcus Oliveira

Preprints:

Ubiquinone deficiency drives reverse electron transport to disrupt hepatic metabolic homeostasis in obesity

Renata L.S. Goncalves, Zeqiu Branden Wang, Karen E. Inouye, Grace Yankun Lee, Xiaorong Fu, Jani Saksi, Clement Rosique, Gunes Parlakgul, Ana Paula Arruda, Sheng Tony Hui, Mar Coll Loperena, Shawn C. Burgess, Isabel Graupera, Gökhan S. Hotamisligil

https://www.biorxiv.org/content/10.1101/2023.02.21.528863v1

This preprint describes how hepatic glucose metabolism is impaired in obesity by demonstrating that reduced ubiquinone biosynthesis in liver mitochondria leads to RET and superoxide production which ultimately drives glucose intolerance. Understanding how hepatic glucose metabolism is affected by obesity is remarkable and sets the ground for the development of rational strategies to improve and overcome glucose intolerance in metabolic diseases.

Categories: biochemistry

 

Posted on: 27 February 2023 , updated on: 28 February 2023

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