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KDM6B-dependent chromatin remodelling underpins effective virus-specific CD8+ T cell differentiation

Jasmine Li, Kristine Hardy, Moshe Olshansky, et al.

Selected by 19 February 2020

Jonny Coates

Immunology

Correction of Niemann-Pick type C1 disease with the histone deacetylase inhibitor valproic acid

Kanagaraj Subramanian, Darren M Hutt, Vijay Gupta, et al.

Selected by 17 September 2019

Joanna Cross

A single-cell transcriptomics CRISPR-activation screen identifies new epigenetic regulators of zygotic genome activation

Celia Alda-Catalinas, Danila Bredikhin, Irene Hernando-Herraez, et al.

Selected by 11 September 2019

Sergio Menchero

Developmental Biology

Hypoxia induces transcriptional and translational downregulation of the type I interferon (IFN) pathway in multiple cancer cell types

Ana Miar, Esther Arnaiz, Esther Bridges, et al.

Selected by 25 August 2019

Jonny Coates

Cancer Biology

The histone chaperone FACT induces Cas9 multi-turnover behavior and modifies genome manipulation in human cells

Alan S. Wang, Leo Chen, R. Alex Wu, et al.

Selected by 20 August 2019

Nicola Stevenson

Molecular Biology

Co-Stimulation–Induced AP-1 Activity is Required for chromatin Opening During T Cell Activation

Masashi Yukawa, Sajjeev Jagannathan, Andrey V. Kartashov, et al.

Selected by 02 August 2019

Jonny Coates

Immunology

Rapid discovery of synthetic DNA sequences to rewrite endogenous T cell circuits

Theodore L. Roth, P. Jonathan Li, Jasper F. Nies, et al.

Selected by 18 June 2019

Pavithran Ravindran

Bioengineering

Resolving the 3D landscape of transcription-linked mammalian chromatin folding

Tsung-Han S. Hsieh, Elena Slobodyanyuk, Anders S. Hansen, et al.

Selected by 13 June 2019

Clarice Hong

Genomics

Prospective, brain-wide labeling of neuronal subclasses with enhancer-driven AAVs

Lucas T Graybuck, Adriana Sedeño-Cortés, Thuc Nghi Nguyen, et al.

Selected by 27 February 2019

Jesus Victorino

Neuroscience

Reconstruction of the global neural crest gene regulatory network in vivo

Ruth M Williams, Ivan Candido-Ferreira, Emmanouela Repapi, et al.

Selected by 28 January 2019

Hannah Brunsdon

Genomics

The coordination of terminal differentiation and cell cycle exit is mediated through the regulation of chromatin accessibility

Yiqin Ma, Daniel J McKay, Laura Buttitta

Selected by 07 January 2019

Gabriel Aughey

Developmental Biology

Promoter-intrinsic and local chromatin features determine gene repression in lamina-associated domains

Christ Leemans, Marloes van der Zwalm, Laura Brueckner, et al.

Selected by 28 November 2018

Carmen Adriaens, Clarice Hong