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Inference of drug off-target effects on cellular signaling using Interactome-Based Deep Learning

Nikolaos Meimetis, Douglas A. Lauffenburger, Avlant Nilsson

NAD+ metabolism is a key modulator of bacterial respiratory epithelial infections

Björn Klabunde, André Wesener, Wilhelm Bertrams, et al.

H₂O₂ sulfenylates CHE linking local infection to establishment of systemic acquired resistance

Lijun Cao, Heejin Yoo, Tianyuan Chen, et al.

Discussion

Nociceptor neuroimmune interactomes reveal cell type- and injury-specific inflammatory pain pathways

Aakanksha Jain, Benjamin M. Gyori, Sara Hakim, et al.

A data-driven Boolean model explains memory subsets and evolution in CD8+ T cell exhaustion

Geena V. Ildefonso, Stacey D. Finley

Remembering immunity: Neuronal ensembles in the insular cortex encode and retrieve specific immune responses

Tamar Koren, Maria Krot, Nadia T. Boshnak, et al.

Discussion

Host defense mechanisms induce genome instability in an opportunistic fungal pathogen

Amanda Smith, Meleah A. Hickman

Discussion

Design of smart antibody mimetics with photosensitive switches

Lian He, Peng Tan, Yun Huang, et al.

Discussion

Transcription repressor protein ZBTB25 interacts with HDAC1 in macrophages infected with Mycobacterium tuberculosis, and its inhibition leads to autophagy and killing of the intracellular pathogen

Aravind Madhavan, K B Arun, Akhil Raj Pushparajan, et al.

AND

Tamoxifen reduces inflammatory infiltration of neutrophils in the airways

Agustín Mansilla, Jaime Soto, Claudio Henríquez, et al.

Discussion

The small RNA ErsA plays a role in the regulatory network of Pseudomonas aeruginosa pathogenicity in airways infection

Silvia Ferrara, Alice Rossi, Serena Ranucci, et al.

Discussion

Tsetse salivary glycoproteins are modified with paucimannosidic N-glycans, are recognised by C-type lectins and bind to trypanosomes

Radoslaw P. Kozak, Karina Mondragon-Shem, Christopher Williams, et al.

Discussion

Dectin-1 limits central nervous system autoimmunity through a non-canonical pathway

M. Elizabeth Deerhake, Keiko Danzaki, Makoto Inoue, et al.

Discussion