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Inference of drug off-target effects on cellular signaling using Interactome-Based Deep Learning

Nikolaos Meimetis, Douglas A. Lauffenburger, Avlant Nilsson

Structured RhoGEF recruitment drives myosin II organization on large exocytotic vesicles

Kumari Kamalesh, Dagan Segal, Ori Avinoam, et al.

The loss of DNA polymerase epsilon accessory subunits POLE3-POLE4 leads to BRCA1-independent PARP inhibitor sensitivity

Hasan Mamar, Roberta Fajka-Boja, Mónika Mórocz, et al.

Metabolomic profiling reveals effects of marein on energy metabolism in HepG2 cells

Baoping Jiang, Liang Le,, Keping Hu, et al.

Discussion

NAD(H) homeostasis is essential for host protection mediated by glycolytic myeloid cells in tuberculosis

Hayden T. Pacl, Krishna C. Chinta, Vineel P. Reddy, et al.

A Phosphoproteomics Data Resource for Systems-level Modeling of kinase Signaling Networks

Song Feng, James A. Sanford, Thomas Weber, et al.

Glial Draper signaling triggers cross-neuron plasticity in bystander neurons after neuronal cell death

Yupu Wang, Ruiling Zhang, Sihao Huang, et al.

Discussion

Coordinated regulation of photosynthesis and translation via NIK1/RPL10/LIMYB signaling module in response to biotic and abiotic stresses

Ruan M. Teixeira, Marco Aurélio Ferreira, Otávio J.B. Brustolini, et al.

Discussion

Polθ is phosphorylated by Polo-like kinase 1 (PLK1) to enable repair of DNA double strand breaks in mitosis

Camille Gelot, Marton Tibor Kovacs, Simona Miron, et al.

Discussion

Coxiella burnetii actively blocks IL-17-induced oxidative stress in macrophages

Tatiana M. Clemente, Leonardo Augusto, Rajendra K. Angara, et al.

Discussion

Phosphorylation controls spatial and temporal activities of motor-PRC1 complexes to complete mitosis

Agata Gluszek-Kustusz, Benjamin Craske, Thibault Legal, et al.

Cell polarity linked to gravity sensing is generated by protein translocation from statoliths to the plasma membrane

Takeshi Nishimura, Shogo Mori, Hiromasa Shikata, et al.

AND

Amyloplast sedimentation repolarizes LAZYs to achieve gravity sensing in plants

Jiayue Chen, Renbo Yu, Na Li, et al.