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Vitamin B12 supports skeletal muscle oxidative phosphorylation capacity in male mice

Luisa F. Castillo, Katarina E. Heyden, Abigail R. Williamson, et al.

Discussion

A high-coverage genome from a 200,000-year-old Denisovan

Stéphane Peyrégne, Diyendo Massilani, Yaniv Swiel, et al.

AND

A global map for introgressed structural variation and selection in humans

PingHsun Hsieh, Natthapon Soisangwan, David S. Gordon, et al.

Discussion

In vitro pharmacokinetics and pharmacodynamics of the diarylquinoline TBAJ-587 and its metabolites against Mycobacterium tuberculosis

Diana Angelica Aguilar-Ayala, Marie Sylvianne Rabodoarivelo, Maxime R. Eveque-Mourroux, et al.

Discussion

Computational design of pH-sensitive binders

Green Ahn, Brian Coventry, Ella Haefner, et al.

High-throughput single-cell CRISPRi screens stratify neurodevelopmental functions of schizophrenia-associated genes

Umut Yildiz, Annique Claringbould, Mikael Marttinen, et al.

Discussion

Tandem duplication of serpin genes yields functional variation and snake venom inhibitors

Meilyn S. Ward, Matthew L. Holding, Laura M. Haynes, et al.

Discussion

Wide-ranging behavioral dysfunction in two mouse models of pathological human variants in the GRIK2 kainate receptor gene

Brynna T. Webb, Hieu Trinh, Emily A. Breach, et al.

Discussion

FUS Mislocalization Rewires a Cortical Gene Network to Drive 2 Cognitive and Behavioral Impairment in ALS

Raphaelle CASSEL, Félicie LORENC, Aurélie BOMBARDIER, et al.

Discussion

A prophage-encoded anti-phage defense system that prevents phage DNA packaging by targeting the terminase complex

Gil Azulay, Nadejda Sigal, Keren Tzohar Rabinovich, et al.

Discussion

Ancestral sequence reconstruction of the Mic60 Mitofilin domain reveals residues supporting respiration in yeast

Friederike M. C. Benning, Tristan A. Bell, Tran H. Nguyen, et al.

Discussion

Discovery of a Potent and Selective Inhibitor of Human NLRP3 with a Novel Binding Modality and Mechanism of Action

Kevin Wilhelmsen, Aditi Deshpande, Sarah Tronnes, et al.

Discussion

Integrin conformation-dependent neutrophil slowing obstructs the capillaries of the pre-metastatic lung in a model of breast cancer

Frédéric Fercoq, Gemma S. Cairns, Marco De Donatis, et al.